BRENDA - Enzyme Database show
show all sequences of 3.4.18.1

Differential expression of cathepsin X in aging and pathological central nervous system of mice

Wendt, W.; Zhu, X.R.; Luebbert, H.; Stichel, C.C.; Exp. Neurol. 204, 525-540 (2007)

Data extracted from this reference:

Engineering
Amino acid exchange
Commentary
Organism
additional information
the enzyme is upregulated in glia cells of degenerating brain regions in a transgenic mouse model of amyotrophic lateral sclerosis, SOD1-G93A, and associated with plaques in transgenic mice expressing the human amyloid precursor protein APP containing the mutation K670M/N671L, overview
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
somal
Homo sapiens
5737
-
cytoplasm
somal, enzyme in close proximity to the mitochondria, the rough endoplasmic reticulum, and the nuclear membrane
Mus musculus
5737
-
lysosome
multivesicular bodies and lipofuscin granules
Mus musculus
5764
-
lysosome
-
Homo sapiens
5764
-
additional information
subcellular localization, overview
Homo sapiens
-
-
additional information
subcellular localization in aged and pathological brain tissues, overview, no activity in the extracellular space
Mus musculus
-
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Homo sapiens
the enzyme is associated with plaques in Alzheimer patients, overview
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Mus musculus
-
wild-type C57BL/6 mice, Alzheimer's double disease mice, and amyotrophic lateral sclerosis SOD1-G93A mice
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
astrocyte
-
Mus musculus
-
brain
the enzyme is associated with plaques in Alzheimer patients, overview
Homo sapiens
-
brain
-
Mus musculus
-
brain stem
-
Homo sapiens
-
brain stem
-
Mus musculus
-
central nervous system
healthy, aging, and pathological, expression patterns of cathepsin X, overview
Mus musculus
-
cerebellum
-
Homo sapiens
-
cerebellum
-
Mus musculus
-
cerebral cortex
of healthy individuals and Alzheimer patients
Homo sapiens
-
cerebral cortex
-
Mus musculus
-
glial cell
-
Homo sapiens
-
glial cell
the enzyme is upregulated in glia cells of degenerating brain regions in a transgenic mouse model of amyotrophic lateral sclerosis
Mus musculus
-
microglia
-
Mus musculus
-
additional information
tissue distribution, immunohistochemic analysis, overview
Homo sapiens
-
additional information
tissue distribution, immunohistochemic analysis, overview
Mus musculus
-
neuron
-
Mus musculus
-
oligodendrocyte
very low enzyme content
Mus musculus
-
spinal cord
-
Homo sapiens
-
spinal cord
-
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
the enzyme is associated with plaques in Alzheimer patients, overview
683448
Homo sapiens
?
-
-
-
-
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.5
-
assay at
Homo sapiens
3.5
-
assay at
Mus musculus
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
the enzyme is upregulated in glia cells of degenerating brain regions in a transgenic mouse model of amyotrophic lateral sclerosis, SOD1-G93A, and associated with plaques in transgenic mice expressing the human amyloid precursor protein APP containing the mutation K670M/N671L, overview
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
somal
Homo sapiens
5737
-
cytoplasm
somal, enzyme in close proximity to the mitochondria, the rough endoplasmic reticulum, and the nuclear membrane
Mus musculus
5737
-
lysosome
multivesicular bodies and lipofuscin granules
Mus musculus
5764
-
lysosome
-
Homo sapiens
5764
-
additional information
subcellular localization, overview
Homo sapiens
-
-
additional information
subcellular localization in aged and pathological brain tissues, overview, no activity in the extracellular space
Mus musculus
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Homo sapiens
the enzyme is associated with plaques in Alzheimer patients, overview
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
astrocyte
-
Mus musculus
-
brain
the enzyme is associated with plaques in Alzheimer patients, overview
Homo sapiens
-
brain
-
Mus musculus
-
brain stem
-
Homo sapiens
-
brain stem
-
Mus musculus
-
central nervous system
healthy, aging, and pathological, expression patterns of cathepsin X, overview
Mus musculus
-
cerebellum
-
Homo sapiens
-
cerebellum
-
Mus musculus
-
cerebral cortex
of healthy individuals and Alzheimer patients
Homo sapiens
-
cerebral cortex
-
Mus musculus
-
glial cell
-
Homo sapiens
-
glial cell
the enzyme is upregulated in glia cells of degenerating brain regions in a transgenic mouse model of amyotrophic lateral sclerosis
Mus musculus
-
microglia
-
Mus musculus
-
additional information
tissue distribution, immunohistochemic analysis, overview
Homo sapiens
-
additional information
tissue distribution, immunohistochemic analysis, overview
Mus musculus
-
neuron
-
Mus musculus
-
oligodendrocyte
very low enzyme content
Mus musculus
-
spinal cord
-
Homo sapiens
-
spinal cord
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
the enzyme is associated with plaques in Alzheimer patients, overview
683448
Homo sapiens
?
-
-
-
-
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.5
-
assay at
Homo sapiens
3.5
-
assay at
Mus musculus
Other publictions for EC 3.4.18.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
732575
Pislar
Cathepsin X promotes 6-hydroxy ...
Rattus norvegicus
Neuropharmacology
82
121-131
2014
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1
1
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731157
Bak
Molecular cloning, expression, ...
Patiria pectinifera
Appl. Biochem. Biotechnol.
169
847-861
2013
4
-
1
-
-
-
9
-
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1
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5
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1
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1
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5
1
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1
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1
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9
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1
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1
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1
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5
1
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1
1
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731770
Chantree
Characterization and expressio ...
Fasciola gigantica
Exp. Parasitol.
132
249-256
2012
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1
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5
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1
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2
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1
1
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732052
Bhutani
Cathepsins L and Z are critica ...
Mus musculus
J. Biol. Chem.
287
17471-17482
2012
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1
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1
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1
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1
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1
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1
1
-
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-
708633
Staudt
Cathepsin X is secreted by hum ...
Homo sapiens
Haematologica
95
1452-1460
2010
-
-
-
-
-
-
-
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2
-
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1
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2
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9
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3
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2
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1
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9
-
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3
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-
-
-
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1
1
-
-
-
708738
Naegler
A cysteine-type carboxypeptida ...
Homo sapiens
Int. Immunopharmacol.
10
134-139
2010
-
1
1
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-
-
-
-
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-
-
2
-
1
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1
1
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4
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1
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1
1
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2
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1
1
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4
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-
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1
-
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1
1
-
2
2
710431
Sevenich
Synergistic antitumor effects ...
Mus musculus
Proc. Natl. Acad. Sci. USA
107
2497-2502
2010
-
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-
-
1
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1
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1
1
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-
693808
Krueger
Regulation of cathepsin X over ...
Homo sapiens
J. Pathol.
217
581-588
2009
1
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1
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3
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4
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4
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708023
Kos
The role of cathepsin X in cel ...
Homo sapiens
Cell Adh. Migr.
3
164-166
2009
-
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1
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1
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2
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3
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1
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1
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1
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3
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1
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1
1
-
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708056
Obermajer
Cathepsin X-mediated beta2 int ...
Homo sapiens
Cell. Mol. Life Sci.
66
1126-1134
2009
-
-
-
-
-
-
1
-
3
-
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1
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1
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2
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1
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1
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3
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1
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2
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1
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1
1
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-
708373
Obermajer
Cathepsin X prevents an effect ...
Homo sapiens
Eur. J. Cell Biol.
88
461-471
2009
-
-
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1
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2
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2
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2
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2
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2
1
1
2
-
-
708379
Jevnikar
Cathepsin X cleaves the beta2 ...
Homo sapiens
Eur. J. Immunol.
39
3217-3227
2009
-
-
1
-
1
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1
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1
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1
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1
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3
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1
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1
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1
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1
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3
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1
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1
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1
1
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708748
Obermajer
Cathepsin X cleaves the C-term ...
Homo sapiens
Int. J. Biochem. Cell Biol.
41
1685-1696
2009
-
-
1
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3
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1
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1
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2
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7
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1
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1
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3
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1
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2
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7
-
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1
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683059
Cooke
Mapping of a novel susceptibil ...
Homo sapiens
Am. J. Respir. Crit. Care Med.
178
203-207
2008
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1
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1
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2
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683222
Bettegowda
Identification of novel bovine ...
Bos taurus
Biol. Reprod.
79
301-309
2008
-
1
1
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1
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1
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683378
Kao
Cloning and expression of carp ...
Cyprinus carpio
Comp. Biochem. Physiol. B
149
541-551
2008
-
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1
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4
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1
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2
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1
1
1
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5
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1
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683533
Obermajer
Cysteine protease cathepsin X ...
Homo sapiens
Immunology
124
76-88
2008
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1
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1
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2
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4
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4
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1
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691910
Ahn
Molecular cloning, tissue dist ...
Paralichthys olivaceus
Comp. Biochem. Physiol. B
151
203-212
2008
-
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1
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12
-
1
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1
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3
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1
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12
2
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2
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1
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2
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1
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12
-
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1
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1
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1
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12
2
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2
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1
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2
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696995
Leichsenring
Differential expression of cat ...
Rattus norvegicus
BMC Neurosci.
9
80
2008
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2
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1
2
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1
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3
1
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1
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683146
Nyfeler
Visualization of protein inter ...
Homo sapiens
Biochem. Soc. Trans.
35
970-973
2007
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2
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