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Literature summary for 3.4.17.3 extracted from
- Carboxypeptidase N: a pleiotropic regulator of inflammation (2004), Mol. Immunol., 40, 785-793.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the enzyme expression level is unaffected by lipopolysaccharides | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene structure comparison, DNA and amino acid sequence determination and analysis | Mus musculus |
| gene structure comparison, DNA and amino acid sequence determination and analysis | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the enzyme expression level is unaffected by lipopolysaccharides | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Homo sapiens | - |
- |
| soluble | - |
Mus musculus | - |
- |
| soluble | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | zinc-metalloprotease | Mus musculus |  |
| Zn2+ | zinc-metalloprotease | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 52000 | - |
2 * 52000, the homodimeric enzyme consists of two small subunits | Mus musculus |
| 52000 | - |
2 * 52000, the homodimeric enzyme consists of two small subunits | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | the enzyme is involved in regulation of inflammation, overview, the enzyme acts as anaphylatoxin inactivator | ? | - |
? | |
| additional information | Homo sapiens | the enzyme is involved in regulation of inflammation, overview, the enzyme acts as anaphylatoxin inactivator | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | - |
Homo sapiens | - |
| intestine | - |
Mus musculus | - |
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| lung | - |
Mus musculus | - |
| additional information | constitutive expression | Mus musculus | - |
| smooth muscle | - |
Mus musculus | - |
| smooth muscle | - |
Homo sapiens | - |
| spleen | - |
Mus musculus | - |
| stomach | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is involved in regulation of inflammation, overview, the enzyme acts as anaphylatoxin inactivator | Mus musculus | ? | - |
? | |
| additional information | the enzyme is involved in regulation of inflammation, overview, the enzyme acts as anaphylatoxin inactivator | Homo sapiens | ? | - |
? | |
| additional information | the enzyme releases C-terminal Arg and Lys from peptide substrates, such as bradykinin, kallidin, or Met-Lys-bradykinin | Mus musculus | ? | - |
? | |
| additional information | the enzyme releases C-terminal Arg and Lys from peptide substrates, such as bradykinin, kallidin, or Met-Lys-bradykinin | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 52000, the homodimeric enzyme consists of two small subunits | Mus musculus |
| dimer | 2 * 52000, the homodimeric enzyme consists of two small subunits | Homo sapiens |
| More | subunit interaction | Mus musculus |
| More | subunit interaction | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| carboxypeptidase N | - |
Mus musculus |
| carboxypeptidase N | - |
Homo sapiens |
| CPN | - |
Homo sapiens |
| CPN1 | - |
Mus musculus |
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