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Literature summary for 3.4.17.23 extracted from

  • Mehrabadi, M.E.; Hemmati, R.; Tashakor, A.; Homaei, A.; Yousefzadeh, M.; Hemati, K.; Hosseinkhani, S.
    Induced dysregulation of ACE2 by SARS-CoV-2 plays a key role in COVID-19 severity (2021), Biomed. Pharmacother., 137, 111363 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.17.23

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface cell-surface non-raft protein with the extracellular N-terminal and intracellular C-terminal domains. Binding to SARS-CoV-2 protein S induces the ACE2 internalization Homo sapiens 9986
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Homo sapiens
-
 angiotensin-(1-9) + Leu
-
 ?
angiotensin II + H2O Homo sapiens
-
 angiotensin(1-7) + L-Phe
-
 ?
QRPRLSHKGPMPF + H2O Homo sapiens i.e. apein(1-13) QRPRLSHKGPMP + L-Phe
-
 ?
YGGFLRRIRPKLK + H2O Homo sapiens i.e. dynorphin A 1-13 YGGFLRRIRPKL + L-Lys
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYF1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
alveolar epithelial cell
-
 Homo sapiens
-
arterial endothelial cell
-
 Homo sapiens
-
arterial smooth muscle
-
 Homo sapiens
-
brain
-
 Homo sapiens
-
cardiac muscle
-
 Homo sapiens
-
enterocyte
-
 Homo sapiens
-
fibroblast cardiac fibroblast Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
lymphocyte within oral mucosa Homo sapiens
-
small intestine
-
 Homo sapiens
-
testis
-
 Homo sapiens
-
vascular endothelium
-
 Homo sapiens
-
venous endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Homo sapiens angiotensin-(1-9) + Leu
-
 ?
angiotensin II + H2O
-
 Homo sapiens angiotensin(1-7) + L-Phe
-
 ?
QRPRLSHKGPMPF + H2O i.e. apein(1-13) Homo sapiens QRPRLSHKGPMP + L-Phe
-
 ?
YGGFLRRIRPKLK + H2O i.e. dynorphin A 1-13 Homo sapiens YGGFLRRIRPKL + L-Lys
-
 ?

Synonyms

Synonyms Comment Organism
ACE2
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism induced dysregulation of the enzyme (ACE2) by SARS-CoV-2 plays a key role in COVID-19 severity. Downregulation of ACE2 can be one of the main causes of SARS-CoV-2 symptoms. COVID-19 severity can be changed by reduction in ACE2 products such as Ang (1-7), Ang (1-9), apelin (1-12) and accumulation of substrates such as apelin (1-13) and Ang II. The downregulation of ACE2, accumulated apelin (1-13) can stimulate the pulmonary embolism Homo sapiens
physiological function key role of the enzyme (ACE2) as a functional receptor for SARSCoV-2 Homo sapiens