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Literature summary for 3.4.17.23 extracted from

  • Wang, W.; McKinnie, S.; Farhan, M.; Paul, M.; McDonald, T.; McLean, B.; Llorens-Cortes, C.; Hazra, S.; Murray, A.; Vederas, J.; Oudit, G.
    Angiotensin-converting enzyme 2 metabolizes and partially inactivates pyr-apelin-13 and apelin-17 Physiological effects in the cardiovascular system (2016), Hypertension, 68, 365-377 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYF1
-
-
Mus musculus Q8R0I0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
apelin 17 + H2O
-
Homo sapiens ?
-
?
pyr-apelin 13 + H2O
-
Homo sapiens ?
-
?

General Information

General Information Comment Organism
physiological function in ACE2 knockout mice, hypotensive action of peptides pyr-apelin 13 and apelin 17 is potentiated, with a corresponding greater elevation in plasma apelin levels. Pyr-apelin 13 and apelin 17 rescue contractile function in a myocardial ischemia-reperfusion model, while ACE2 cleavage products, pyr-apelin 12 and 16, are devoid of these cardioprotective effects. Pharmacological inhibition of ACE2 potentiates the vasodepressor action of apelin peptides. Loss of C-terminal phenylalanine attenuates apelin peptide physiological effects Mus musculus
physiological function recombinant human ACE2 can cleave pyr-apelin 13 and apelin 17 efficiently, and apelin peptides are degraded slower in ACE2-deficient plasma Homo sapiens