Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BYF1 | - |
- |
Mus musculus | Q8R0I0 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
apelin 17 + H2O | - |
Homo sapiens | ? | - |
? | |
pyr-apelin 13 + H2O | - |
Homo sapiens | ? | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | in ACE2 knockout mice, hypotensive action of peptides pyr-apelin 13 and apelin 17 is potentiated, with a corresponding greater elevation in plasma apelin levels. Pyr-apelin 13 and apelin 17 rescue contractile function in a myocardial ischemia-reperfusion model, while ACE2 cleavage products, pyr-apelin 12 and 16, are devoid of these cardioprotective effects. Pharmacological inhibition of ACE2 potentiates the vasodepressor action of apelin peptides. Loss of C-terminal phenylalanine attenuates apelin peptide physiological effects | Mus musculus |
physiological function | recombinant human ACE2 can cleave pyr-apelin 13 and apelin 17 efficiently, and apelin peptides are degraded slower in ACE2-deficient plasma | Homo sapiens |