Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.17.23 extracted from

  • Meng, Y.; Li, T.; Zhou, G.; Chen, Y.; Yu, C.; Pang, M.; Li, W.; Li, Y.; Zhang, W.; Li, X.
    The angiotensin-converting enzyme 2/angiotensin (1-7)/mas axis protects against lung fibroblast migration and lung fibrosis by inhibiting the NOX4-derived ROS-mediated RhoA/Rho kinase pathway (2015), Antioxid. Redox Signal., 22, 241-258 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.17.23

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q5EGZ1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast primary lung fibroblast Rattus norvegicus
-
lung
-
 Rattus norvegicus
-

General Information

General Information Comment Organism
physiological function in vitro, AngII significantly increases the NOX4 level and ROS production in lung fibroblasts, which stimulates cell migration and alpha-collagen I synthesis through the RhoA/Rock pathway. These effects are attenuated by N-acetylcysteine, diphenylene iodonium, and NOX4 RNA interference. Angiotensin (1-7) and lentivirus-mediated ACE2 suppress angiotensin II-induced migration and alpha-collagen I synthesis by inhibiting the NOX4-derived ROS-mediated RhoA/Rock pathway. In vivo, constant infusion with angiotensin (1-7) or intratracheal instillation with lentivirus-mediated ACE2 shift the renin-angiotensin system balance toward the ACE2/angiotensin (1-7)/Mas axis, alleviate bleomycin-induced lung fibrosis, and inhibit the RhoA/Rock pathway by reducing NOX4-derived ROS Rattus norvegicus