Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.17.23 extracted from

  • Towler, P.; Staker, B.; Prasad, S.G.; Menon, S.; Tang, J.; Parsons,T.; Ryan, D.; Fisher, M.; Williams, D.; Dales, N.A.; Patane, M.A.; Pantoliano, M.W.
    ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis (2004), J. Biol. Chem., 279, 17996-18007.
    View publication on PubMed
Search for more literature for 3.4.17.23

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion at 16-18°C, crystal structures of the native and inhibitor(MLN-4760)-bound forms of the ACE2 extracellular domains are solved to 2.2 and 3.0 A resolution, respectively Homo sapiens
hanging drop vapor diffusion at 16-18°C, crystal structures of the native and inhibitor-bound forms of the ACE2 extracellular domains are solved to 2.2 A and 3.0 A resolution Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(S,S)-2-{1-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl]-ethylamino}-4-methylpentanoic acid i.e MLN-4760 Homo sapiens
MLN-4760 i.e. ((S,S)-2-[1-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-imidazol4-yl]-ethylamino]-4-methylpentanoic acid) Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane integral membrane protein Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens ACE2 is involved in the regulation of heart function, ACE 2 is a functional receptor for the coronavirus that causes the severe acute respiratory syndrome ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYF1
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant Homo sapiens
recombinant truncated extracellular form of human ACE2 (residues 1–740) Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ACE2 is involved in the regulation of heart function, ACE 2 is a functional receptor for the coronavirus that causes the severe acute respiratory syndrome Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ACE2
-
 Homo sapiens