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Literature summary for 3.4.17.23 extracted from

  • Li, X.; Molina-Molina, M.; Abdul-Hafez, A.; Uhal, V.; Xaubet, A.; Uhal, B.D.
    Angiotensin converting enzyme-2 is protective but downregulated in human and experimental lung fibrosis (2008), Am. J. Physiol. Lung Cell Mol. Physiol., 295, L178-185.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine ACE-2 protects against lung fibrogenesis by limiting the local accumulation of the profibrotic peptide angiotensin II Mus musculus
medicine ACE-2 protects against lung fibrogenesis by limiting the local accumulation of the profibrotic peptide angiotensin II Homo sapiens
medicine ACE-2 protects against lung fibrogenesis by limiting the local accumulation of the profibrotic peptide angiotensin II Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
DX600 competitive inhibitor, 0.1 mM Homo sapiens
DX600 competitive inhibitor, 0.1 mM Mus musculus
DX600 competitive inhibitor, 0.1 mM Rattus norvegicus
additional information ACE-2 mRNA and activity are severely downregulated in lung fibrosis Homo sapiens
additional information ACE-2 mRNA and activity are severely downregulated in lung fibrosis Mus musculus
additional information ACE-2 mRNA and activity are severely downregulated in lung fibrosis Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)-acetyl-YVADAPK-(2,4-dinitrophenyl)-OH + H2O
-
Mus musculus (7-methoxycoumarin-4-yl)-acetyl-YVADAP + N6-(2,4-dinitrophenyl)-L-Lys
-
?
(7-methoxycoumarin-4-yl)-acetyl-YVADAPK-(2,4-dinitrophenyl)-OH + H2O
-
Homo sapiens (7-methoxycoumarin-4-yl)-acetyl-YVADAP + N6-(2,4-dinitrophenyl)-L-Lys
-
?
(7-methoxycoumarin-4-yl)-YVADAPK-(2,4-dinitrophenyl)-OH + H2O
-
Rattus norvegicus (7-methoxycoumarin-4-yl)-YVADAP + N6-(2,4-dinitrophenyl)-L-lysine
-
?
angiotensin II + H2O
-
Mus musculus angiotensin-(1-7) + Phe
-
?
angiotensin II + H2O
-
Homo sapiens angiotensin-(1-7) + Phe
-
?
angiotensin II + H2O
-
Rattus norvegicus angiotensin-(1-7) + Phe
-
?

Synonyms

Synonyms Comment Organism
ACE-2
-
Mus musculus
ACE-2
-
Homo sapiens
ACE-2
-
Rattus norvegicus
angiotensin converting enzyme-2
-
Mus musculus
angiotensin converting enzyme-2
-
Homo sapiens
angiotensin converting enzyme-2
-
Rattus norvegicus