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Literature summary for 3.4.17.23 extracted from

  • Imai, Y.; Kuba, K.; Rao, S.; Huan, Y.; Guo, F.; Guan, B.; Yang, P.; Sarao, R.; Wada, T.; Leong-Poi, H.; Crackower, M.A.; Fukamizu, A.; Hui, C.C.; Hein, L.; Uhlig, S.; Slutsky, A.S.; Jiang, C.; Penninger, J.M.
    Angiotensin-converting enzyme 2 protects from severe acute lung failure (2005), Nature, 436, 112-116.
    View publication on PubMed

Application

Application Comment Organism
medicine recombinant ACE2 can protect mice from severe acute lung injury Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
lung ACE2 and the AT2 receptor protect against lung injury. Exogenous recombinant human ACE2 attenuates acute lung failure in Ace knockout as well as in wild-type mice. Acute lung injury results in a marked downregulation of ACE2. Loss of ACE2 expression in acute lung injury leads to leaky pulmonary blood vessels through AT1 receptor stimulation Mus musculus
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