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Literature summary for 3.4.17.23 extracted from

  • Warner, F.J.; Lew, R.A.; Smith, A.I.; Lambert, D.W.; Hooper, N.M.; Turner, A.J.
    Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells (2005), J. Biol. Chem., 280, 39353-39362.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in CHO cells and polarized Madin-Darby canine kidney epithelial cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
MLN4760
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane evenly distributed to detergent-soluble regions of the plasma membrane in non-polarized CHO cells, in polarized Madin-Darby canine kidney epithelial cells ACE is localized predominantly to the apical surface (92%) where it is proteolytically cleaved within the ectodomain to release a soluble form, recombinantly expressed enzymes Homo sapiens 5886
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Homo sapiens
-
kidney
-
 Homo sapiens
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urine
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)acetyl-Ala-Pro-Lys(2,4-dinitrophenyl) + H2O
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 Homo sapiens (7-methoxycoumarin-4-yl)acetyl-Ala-Pro + N6-(2,4-dinitrophenyl)-L-lysine
-
 ?

Synonyms

Synonyms Comment Organism
ACE2
-
 Homo sapiens