Literature summary for 3.4.17.22 extracted from

Tong, Y.; Tong, S.; Zhao, X.; Wang, J.; Jun, J.; Park, J.; Wands, J.; Li, J.
Initiation of duck hepatitis B virus infection requires cleavage by a furin-like protease (2010), J. Virol., 84, 4569-4578.

Search for more literature for 3.4.17.22

Cloned(Commentary)

Cloned (Comment)	Organism
expressed by transient expression in a human kidney cell line and primary duck hepatocytes	Anas platyrhynchos

Protein Variants

Protein Variants	Comment	Organism
R166A/R169A	enzyme is cleaved by furin. Proteins sequence reveals a consensus sequence for furin cleavage (RXXR) at positions 166 to 169. Cleavage at this site removes the N-terminal 169 residues to generate a truncated protein of approximately 151 kDa. Substitution of the two arginines with alanine completely abolishes cleavage of DCPD	Anas platyrhynchos

Inhibitors

Inhibitors	Comment	Organism	Structure
dynorphin A	-	Anas platyrhynchos
Met-enkephalin-KK	-	Anas platyrhynchos

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endosome	DCPD, glycine decarboxylase and duck Hepatitis B virus large enveloppe protein are colocalized in the endosomal fraction of duck hepatocytes	Anas platyrhynchos	5768	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
170000	-	SDS-PAGE	Anas platyrhynchos

Organism

Organism	UniProt	Comment	Textmining
Anas platyrhynchos	Q90240	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	enzyme is cleaved by furin. Proteins sequence reveals a consensus sequence for furin cleavage (RXXR) at positions 166 to 169. Cleavage at this site removes the N-terminal 169 residues to generate a truncated protein of approximately 151 kDa. Substitution of the two arginines with alanine completely abolishes cleavage of DCPD	Anas platyrhynchos

Synonyms

Synonyms	Comment	Organism
DCPD	-	Anas platyrhynchos
duck carboxypeptidase D	-	Anas platyrhynchos

General Information

General Information	Comment	Organism
physiological function	transfected DCPD could confer duck hepatitis B virus binding to non-duck cell lines which is followed by rapid virus release from cells. Coexpression of furin leads to DCPD cleavage and increases virus retention	Anas platyrhynchos

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Release 2023.1 (January 2023)