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Literature summary for 3.4.17.22 extracted from

  • Hoff, N.P.; Degrandi, D.; Hengge, U.; Pfeffer, K.; Wurthner, J.U.
    Carboxypeptidase D: a novel TGF-beta target gene dysregulated in patients with lupus erythematosus (2007), J. Clin. Immunol., 27, 568-579.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
transforming growth factor-beta leads to upregulation of CpD in primary human blood monocytes. Does not upregulate CpD in HepG2 cells Homo sapiens
transforming growth factor-beta upregulates CpD in ANA-1 cells and RAW 264.7 cells Mus musculus

Application

Application Comment Organism
medicine CpD is significantly downregulated in CD14 positive cells isolated from patients with lupus erythematosus. Moreover, it is shown that downregulation of CpD leads to downmodulation of TGF-beta itself, suggesting a role for CpD in a positive feedback loop, providing further evidence for a role of this enzyme in lupus erythematosus Homo sapiens
medicine CpD is part of an autoregulatory feedback loop in which it is both upstream and downstream of transforming growth factor-beta signaling Mus musculus
medicine CpD is part of the transforming growth factor-beta pathway and is dysregulated in patients with Lupus erythematosus and other autoimmune diseases Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
siRNA downregulation of CpD by siRNA leads to downregulation of transforming growth factor-beta Homo sapiens
siRNA downregulates CpD by about 80% in RAW 264.7 cells Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
180000
-
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens O75976
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ANA-1 cell baseline expression Mus musculus
-
Hep-G2 cell baseline expression Homo sapiens
-
macrophage
-
Mus musculus
-
macrophage cell line it is demonstrated that CpD is up-regulated by TGF-beta in murine macrophage cell lines ANA-1 and RAW 264.7 but HepG2 cells - cells not primarily associated with innate immune responses- show only minimal regulation of CpD by TGF-beta Mus musculus
-
monocyte
-
Homo sapiens
-
monocyte it is demonstrated that CpD is up-regulated by TGF-beta in CD14 + human blood monocytes Homo sapiens
-
additional information CpD is significantly downregulated in CD14 positive cells isolated from patients with rheumatoid arthritis, Takayasu’s arteritis, multiple sclerosis, systemic lupus erythematosus as compared to healthy controls Homo sapiens
-
RAW-264.7 cell
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
Carboxypeptidase D
-
Mus musculus
Carboxypeptidase D
-
Homo sapiens
CPD
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Mus musculus
CPD
-
Homo sapiens