Activating Compound | Comment | Organism | Structure |
---|---|---|---|
transforming growth factor-beta | leads to upregulation of CpD in primary human blood monocytes. Does not upregulate CpD in HepG2 cells | Homo sapiens | |
transforming growth factor-beta | upregulates CpD in ANA-1 cells and RAW 264.7 cells | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | CpD is significantly downregulated in CD14 positive cells isolated from patients with lupus erythematosus. Moreover, it is shown that downregulation of CpD leads to downmodulation of TGF-beta itself, suggesting a role for CpD in a positive feedback loop, providing further evidence for a role of this enzyme in lupus erythematosus | Homo sapiens |
medicine | CpD is part of an autoregulatory feedback loop in which it is both upstream and downstream of transforming growth factor-beta signaling | Mus musculus |
medicine | CpD is part of the transforming growth factor-beta pathway and is dysregulated in patients with Lupus erythematosus and other autoimmune diseases | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
siRNA | downregulation of CpD by siRNA leads to downregulation of transforming growth factor-beta | Homo sapiens | |
siRNA | downregulates CpD by about 80% in RAW 264.7 cells | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
180000 | - |
- |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | O75976 | - |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ANA-1 cell | baseline expression | Mus musculus | - |
Hep-G2 cell | baseline expression | Homo sapiens | - |
macrophage | - |
Mus musculus | - |
macrophage cell line | it is demonstrated that CpD is up-regulated by TGF-beta in murine macrophage cell lines ANA-1 and RAW 264.7 but HepG2 cells - cells not primarily associated with innate immune responses- show only minimal regulation of CpD by TGF-beta | Mus musculus | - |
monocyte | - |
Homo sapiens | - |
monocyte | it is demonstrated that CpD is up-regulated by TGF-beta in CD14 + human blood monocytes | Homo sapiens | - |
additional information | CpD is significantly downregulated in CD14 positive cells isolated from patients with rheumatoid arthritis, Takayasus arteritis, multiple sclerosis, systemic lupus erythematosus as compared to healthy controls | Homo sapiens | - |
RAW-264.7 cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
Carboxypeptidase D | - |
Mus musculus |
Carboxypeptidase D | - |
Homo sapiens |
CPD | - |
Mus musculus |
CPD | - |
Homo sapiens |