Literature summary for 3.4.17.22 extracted from

O'Malley, P.G.; Sangster, S.M.; Abdelmagid, S.A.; Bearne, S.L.; Too, C.K.
Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells (2005), Biochem. J., 390, 665-673.

Search for more literature for 3.4.17.22

Inhibitors

Inhibitors	Comment	Organism	Structure
1,10-phenanthroline	-	Rattus norvegicus
DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid	-	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.063	-	Dansyl-Ala-Arg	0.1 M sodium acetate, 37°C	Rattus norvegicus
0.132	-	Dansyl-Ala-Arg	0.1 M sodium acetate, 37°C	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	also detectable in the cytosol after 24 h treatment with interleukin-2	Rattus norvegicus	5634	-
perinuclear space	-	Rattus norvegicus	-	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
160000	-	SDS-PAGE	Rattus norvegicus
180000	-	SDS-PAGE	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-
Rattus norvegicus	Q9JHW1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lymphoma cell line	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Dansyl-Ala-Arg + H2O	-	Rattus norvegicus	Dansyl-Ala + Arg	-	?

Synonyms

Synonyms	Comment	Organism
carboxypeptidase-D	-	Rattus norvegicus
CPD	-	Rattus norvegicus
CPD-N	-	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
5.6	-	-	Rattus norvegicus
7	-	domain I is most active at pH 7 whereas domain II is most active at pH 5.6	Rattus norvegicus

pH Range

pH Minimum	pH Maximum	Comment	Organism
5	7	-	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0093	-	DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid	-	Rattus norvegicus
0.0116	-	1,10-phenanthroline	-	Rattus norvegicus
0.0451	-	1,10-phenanthroline	-	Rattus norvegicus
0.0476	-	DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid	-	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)