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Literature summary for 3.4.17.21 extracted from

  • Xi, Z.X.; Li, X.; Peng, X.Q.; Li, J.; Chun, L.; Gardner, E.L.; Thomas, A.G.; Slusher, B.S.; Ashby, C.R.
    Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism (2010), J. Neurochem., 112, 564-576.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2-(phosphonomethyl)pentanedioic acid i.e. 2-PMPA, a N-acetylated-alpha-linkedacidic dipeptidase inhibitor, attenuates cocaine self-administration and cocaine-induced reinstatement of drug seeking of rats Rattus norvegicus
GPI-5693
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-L-aspartyl-L-glutamate + H2O Rattus norvegicus
-
L-glutamate + N-acetyl-L-aspartate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male Long-Evans rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-L-aspartyl-L-glutamate + H2O
-
Rattus norvegicus L-glutamate + N-acetyl-L-aspartate
-
?

Synonyms

Synonyms Comment Organism
N-Acetylated-alpha-linked-acidic dipeptidase
-
Rattus norvegicus
NAALADase
-
Rattus norvegicus

General Information

General Information Comment Organism
malfunction involvement of the endogenous NAAG-NAALADase signaling pathway in cocaine addiction. Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats via a NAAG-mGluR2/3-mediated mechanism, overview Rattus norvegicus