Literature summary for 3.4.17.21 extracted from

Peng, X.Q.; Li, J.; Gardner, E.L.; Ashby, C.R.; Thomas, A.; Wozniak, K.; Slusher, B.S.; Xi, Z.X.
Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats (2010), Eur. J. Pharmacol., 627, 156-161.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-(3-sulfanylpropyl)pentanedioic acid	i.e. GPI-5693, attenuates cocaine-induced conditioned place preference	Rattus norvegicus
2-(phosphonomethyl)pentanedioic acid	i.e. 2-PMPA, inhibits cocaine-induced behavioural sensitization	Rattus norvegicus
GPI-16476	enantiomer of GPI-5693	Rattus norvegicus
GPI-16477	enantiomer of GPI-5693	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
N-acetyl-L-aspartyl-L-glutamate + H2O	Rattus norvegicus	-	L-glutamate + N-acetyl-L-aspartate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male Long-Evans rats	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-acetyl-L-aspartyl-L-glutamate + H2O	-	Rattus norvegicus	L-glutamate + N-acetyl-L-aspartate	-	?

Synonyms

Synonyms	Comment	Organism
N-Acetylated-alpha-linked-acidic dipeptidase	-	Rattus norvegicus
NAAG degradation enzyme	-	Rattus norvegicus
NAALADase	-	Rattus norvegicus

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Release 2023.1 (January 2023)