Literature summary for 3.4.17.21 extracted from

Hillier, S.M.; Maresca, K.P.; Femia, F.J.; Marquis, J.C.; Foss, C.A.; Nguyen, N.; Zimmerman, C.N.; Barrett, J.A.; Eckelman, W.C.; Pomper, M.G.; Joyal, J.L.; Babich, J.W.
Preclinical evaluation of novel glutamate-urea-lysine analogues that target prostate-specific membrane antigen as molecular imaging pharmaceuticals for prostate cancer (2009), Cancer Res., 69, 6932-6940.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(S)-2-(3-((S)-1-carboxy-5-(3-(4-iodophenyl)ureido)pentyl)ureido)pentanedioic acid	i.e. MIP-1095, the compound shows affinity to and uptake into prostate cancer cells, binding analysis, overview	Homo sapiens
(S)-2-(3-((S)-1-carboxy-5-(4-iodobenzylamino)pentyl)ureido)pentanedioic acid	i.e. MIP-1072, the compound shows affinity to and uptake into prostate cancer cells, binding analysis, overview	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
LNCaP cell	-	Homo sapiens	-
additional information	PC-3 cells lack PSMA	Homo sapiens	-
prostate cancer cell	highly up-regulated PSMA	Homo sapiens	-
prostate epithelium	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
glutamate carboxypeptidase	-	Homo sapiens
Prostate-specific membrane antigen	-	Homo sapiens
PSMA	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00000024	-	(S)-2-(3-((S)-1-carboxy-5-(3-(4-iodophenyl)ureido)pentyl)ureido)pentanedioic acid	-	Homo sapiens
0.0000046	-	(S)-2-(3-((S)-1-carboxy-5-(4-iodobenzylamino)pentyl)ureido)pentanedioic acid	-	Homo sapiens

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Release 2023.1 (January 2023)