Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-2-(3-mercaptopropyl)-pentanedioic acid | equally potent as the S-isomer, 0.000085 mM | Homo sapiens | |
(R)-2-(3-mercaptopropyl)-pentanedioic acid | antinociceptide effects in the chronic constriction injury model, cell culture model of cerebral ischemia | Rattus norvegicus | |
(R)-2-(hydroxypentafluorophenylmethyl-phosphinoylmethyl)pentanedioic acid | 40fold less potent than the S-isomer, IC50: 0.0014 mM | Homo sapiens | |
(R)-2-(hydroxypentafluorophenylmethyl-phosphinoylmethyl)pentanedioic acid | neuroprotective effects in the middle cerebral artery occlusion model, cell culture model of cerebral ischemia | Rattus norvegicus | |
(R)-2-(phosphonomethyl)-pentanedioic acid | less potent than the S-isomer, IC50: 0.000030 mM | Homo sapiens | |
(R)-2-(phosphonomethyl)-pentanedioic acid | - |
Rattus norvegicus | |
(S)-2-(3-mercaptopropyl)-pentanedioic acid | equally potent as the R-isomer, 0.000067 mM | Homo sapiens | |
(S)-2-(3-mercaptopropyl)-pentanedioic acid | antinociceptide effects in the chronic constriction injury model, cell culture model of cerebral ischemia | Rattus norvegicus | |
(S)-2-(hydroxypentafluorophenylmethyl-phosphinoylmethyl)pentanedioic acid | 40fold more potent than the R-isomer, IC50: 0.000034 mM | Homo sapiens | |
(S)-2-(hydroxypentafluorophenylmethyl-phosphinoylmethyl)pentanedioic acid | neuroprotective effects in the middle cerebral artery occlusion model, cell culture model of cerebral ischemia | Rattus norvegicus | |
(S)-2-(phosphonomethyl)-pentanedioic acid | more potent than the R-isomer, IC50: 0.0000001 mM | Homo sapiens | |
(S)-2-(phosphonomethyl)-pentanedioic acid | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | Homo sapiens | - |
N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | Rattus norvegicus | - |
N-acetyl-alpha-L-aspartate + L-glutamate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | cerebral ischemia cell culture model | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | - |
Homo sapiens | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | - |
Rattus norvegicus | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | enantiospecific reaction | Homo sapiens | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | enantiospecific reaction | Rattus norvegicus | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCP II | - |
Homo sapiens |
GCP II | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000001 | - |
more potent than the R-isomer, IC50: 0.0000001 mM | Homo sapiens | (S)-2-(phosphonomethyl)-pentanedioic acid | |
0.00003 | - |
less potent than the S-isomer, IC50: 0.000030 mM | Homo sapiens | (R)-2-(phosphonomethyl)-pentanedioic acid | |
0.000034 | - |
40fold more potent than the R-isomer, IC50: 0.000034 mM | Homo sapiens | (S)-2-(hydroxypentafluorophenylmethyl-phosphinoylmethyl)pentanedioic acid | |
0.0014 | - |
40fold less potent than the S-isomer, IC50: 0.0014 mM | Homo sapiens | (R)-2-(hydroxypentafluorophenylmethyl-phosphinoylmethyl)pentanedioic acid |