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Literature summary for 3.4.17.21 extracted from
- Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer (2004), J. Cell. Biochem., 91, 528-539.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene FOLH1, DNA sequence variants analysis, expression regulation by PMSA enhancer, PSME, involving Ca2+, overview, localization on chromosome 11p11-12, another highly homologous gene is located at 11q14.3 and is expressed in several tissues, e.g. kidney and liver, but not in prostate | Homo sapiens |
| gene PMSA, DNA sequence variants analysis, expression regulation by PMSA enhancer, PSME, involving Ca2+, overview | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the androgen receptor negatively regulates the enzyme expression | Homo sapiens | |
| additional information | the androgen receptor negatively regulates the enzyme expression | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Rattus norvegicus | 5886 | - |
| plasma membrane | the enzyme is a type II membrane glycoprotein with an intracellular segment, a transmembrane domain, and an extensive extracellular domain | Mus musculus | 5886 | - |
| plasma membrane | the enzyme is a type II membrane glycoprotein with an intracellular segment, a transmembrane domain, and an extensive extracellular domain | Homo sapiens | 5886 | - |
| synapse | neuronal | Mus musculus | 45202 | - |
| synapse | neuronal | Homo sapiens | 45202 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | positively regulates enzyme expression | Mus musculus |  |
| Ca2+ | positively regulates enzyme expression | Homo sapiens | |
| Zn2+ | involved in substrate binding | Mus musculus | |
| Zn2+ | involved in substrate binding | Homo sapiens | |
| Zn2+ | involved in substrate binding | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | the enzyme interacts with filamin leading to internalization of PMSA into cells in the perinuclear region, overview | ? | - |
? | |
| additional information | Homo sapiens | the enzyme interacts with filamin leading to internalization of PMSA into cells in the perinuclear region, overview | ? | - |
? | |
| N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | Homo sapiens | i.e. NAAG, a neurodipeptide, the enzyme acts as membrane-bound receptor being recycled through clathrin coated pits, expression regulation within cells and involvement in prostate cancer and metastasis, overview | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
| N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | Mus musculus | i.e. NAAG, a neurodipeptide, the enzyme acts as membrane-bound receptor being recycled through clathrin coated pits, expression regulation within cells in prostate cancer and metastasis, overview | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
| N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | Rattus norvegicus | i.e. NAAG, a neurodipeptide, the enzyme acts as membrane-bound receptor being recycled through clathrin coated pits, expression regulation within cells in prostate cancer and metastasis, overview | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
| poly-gamma-glutamate folate + H2O | Mus musculus | activity outside of the cell | ? | - |
? | |
| poly-gamma-glutamate folate + H2O | Homo sapiens | activity outside of the cell | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
bifunctional enzyme, gene PMSA | - |
| Mus musculus | - |
bifunctional enzyme, gene folh1 | - |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | the enzyme is a type II membrane glycoprotein | Mus musculus |
| glycoprotein | the enzyme is a type II membrane glycoprotein | Homo sapiens |
| glycoprotein | the enzyme is a type II membrane glycoprotein | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| prostate carcinoma cell | - |
Mus musculus | - |
| prostate carcinoma cell | - |
Homo sapiens | - |
| prostate gland | - |
Mus musculus | - |
| prostate gland | - |
Homo sapiens | - |
| prostate gland | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme interacts with filamin leading to internalization of PMSA into cells in the perinuclear region, overview | Mus musculus | ? | - |
? | |
| additional information | the enzyme interacts with filamin leading to internalization of PMSA into cells in the perinuclear region, overview | Homo sapiens | ? | - |
? | |
| additional information | bifunctional enzyme performing folate hydrolase and N-acetylated alpha-linked acidic dipeptidase, NAALADase, activities | Mus musculus | ? | - |
? | |
| additional information | bifunctional enzyme performing folate hydrolase and N-acetylated alpha-linked acidic dipeptidase, NAALADase, activities | Homo sapiens | ? | - |
? | |
| N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | - |
Mus musculus | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
| N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | - |
Homo sapiens | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
| N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | - |
Rattus norvegicus | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
| N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | i.e. NAAG, a neurodipeptide, the enzyme acts as membrane-bound receptor being recycled through clathrin coated pits, expression regulation within cells and involvement in prostate cancer and metastasis, overview | Homo sapiens | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
| N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | i.e. NAAG, a neurodipeptide, the enzyme acts as membrane-bound receptor being recycled through clathrin coated pits, expression regulation within cells in prostate cancer and metastasis, overview | Mus musculus | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
| N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | i.e. NAAG, a neurodipeptide, the enzyme acts as membrane-bound receptor being recycled through clathrin coated pits, expression regulation within cells in prostate cancer and metastasis, overview | Rattus norvegicus | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
| poly-gamma-glutamate folate + H2O | - |
Mus musculus | ? | - |
? | |
| poly-gamma-glutamate folate + H2O | - |
Homo sapiens | ? | - |
? | |
| poly-gamma-glutamate folate + H2O | activity outside of the cell | Mus musculus | ? | - |
? | |
| poly-gamma-glutamate folate + H2O | activity outside of the cell | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | the enzyme is a is monomeric or dimeric type II membrane glycoprotein with an intracellular segment, a transmembrane domain, and an extensive extracellular domain | Mus musculus |
| More | the enzyme is a type II membrane glycoprotein with an intracellular segment, a transmembrane domain, and an extensive extracellular domain | Rattus norvegicus |
| More | the enzyme is monomeric or dimeric a type II membrane glycoprotein with an intracellular segment of amino acid residues 1-18, a transmembrane domain of residues 19-43, and an extensive extracellular domain comprising residues 44-750 | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FOLH1 | - |
Mus musculus |
| FOLH1 | - |
Homo sapiens |
| N-Acetylated alpha-linked acidic dipeptidase | - |
Mus musculus |
| N-Acetylated alpha-linked acidic dipeptidase | - |
Homo sapiens |
| N-Acetylated alpha-linked acidic dipeptidase | - |
Rattus norvegicus |
| NAALADase | - |
Mus musculus |
| NAALADase | - |
Homo sapiens |
| NAALADase | - |
Rattus norvegicus |
| prostate specific membrane antigen | - |
Mus musculus |
| prostate specific membrane antigen | - |
Homo sapiens |
| PSMA | - |
Mus musculus |
| PSMA | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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