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Literature summary for 3.4.17.21 extracted from

  • Ghosh, A.; Wang, X.; Klein, E.; Heston, W.D.
    Novel role of prostate-specific membrane antigen in suppressing prostate cancer invasiveness (2005), Cancer Res., 65, 727-731.
    View publication on PubMed
Search for more literature for 3.4.17.21

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant enzymes in PC3 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
H380G site-directed mutagenesis, active site mutant, inactive mutant Homo sapiens
L4A/L5A site-directed mutagenesis, internalization motif mutant, active mutant, no endocytic internalization Homo sapiens
N336A site-directed mutagenesis, glycosylation site E mutant, inactive mutant, no endocytic internalization Homo sapiens
N459A site-directed mutagenesis, glycosylation site E mutant, inactive mutant, no endocytic internalization Homo sapiens
N476A site-directed mutagenesis, glycosylation site E mutant, inactive mutant, no iendocytic nternalization Homo sapiens
N638A site-directed mutagenesis, glycosylation site F mutant, inactive mutant Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-
plasma membrane type II transmembrane glycoprotein Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O Homo sapiens the enzyme is involved in suppressing prostate cancer invasiveness N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein type II transmembrane glycoprotein Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
CWR22Rv1 cell
-
 Homo sapiens
-
epithelium
-
 Homo sapiens
-
LNCaP cell originating from a prostate cancer lymph node metastasis Homo sapiens
-
prostate cancer cell overexpression of the enzyme in prostate cancer Homo sapiens
-
prostate gland epithelial cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O
-
 Homo sapiens N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O the enzyme is involved in suppressing prostate cancer invasiveness Homo sapiens N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
PMSA
-
 Homo sapiens
Prostate-specific membrane antigen
-
 Homo sapiens