Cloned (Comment) | Organism |
---|---|
expression in CHO cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S)-2-[([[(1S)-1,3-dicarboxypropyl]amino]carbonyl)amino]pentanedioic acid | - |
Homo sapiens | |
(2S)-2-[([[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]carbonyl)amino]pentanedioic acid | the inhibitor has the ability to reduce the perception of inflammatory pain | Homo sapiens | |
(2S)-2-[([[(1S)-1-carboxy-2-phenylethyl]amino]carbonyl)amino]pentanedioic acid | - |
Homo sapiens | |
(2S)-2-[([[(1S)-1-carboxy-3-(1H-tetrazol-5-yl)propyl]amino]carbonyl)amino]pentanedioic acid | - |
Homo sapiens | |
(2S)-2-[([[(1S)-1-carboxy-3-(2H-tetrazol-5-yl)propyl]amino]carbonyl)amino]-4-(2H-tetrazol-5-yl)butanoic acid | - |
Homo sapiens | |
(2S)-2-[([[(1S)-3-carboxy-1-(2H-tetrazol-5-yl)propyl]amino]carbonyl)amino]pentanedioic acid | - |
Homo sapiens | |
(2S)-2-[([[(S)-carboxy(4-hydroxyphenyl)methyl]amino]carbonyl)amino]pentanedioic acid | - |
Homo sapiens | |
(2S)-2-[[([(1S)-1-carboxy-3-[1-(2-cyanoethyl)-1H-tetrazol-5-yl]propyl]amino)carbonyl]amino]pentanedioic acid | - |
Homo sapiens | |
(2S)-2-[[([(1S)-3-carboxy-1-[2-(2-cyanoethyl)-2H-tetrazol-5-yl]propyl]amino)carbonyl]amino]pentanedioic acid | - |
Homo sapiens | |
(2S,2'S,4R)-4-benzyl-N,N'-carbonyldiglutamic acid | - |
Homo sapiens | |
(2S,2'S,4R,4'R)-4,4'-dibenzyl-N,N'-carbonyldiglutamic acid | - |
Homo sapiens | |
(2S,2'S,4R,4'R)-N,N'-carbonyl-4,4'-dimethyldiglutamic acid | - |
Homo sapiens | |
(2S,2'S,4S)-N,N'-carbonyl-4-methyldiglutamic acid | - |
Homo sapiens | |
(2S,2'S,4S,4'S)-N,N'-carbonyl-4,4'-dimethyldiglutamic acid | - |
Homo sapiens | |
(2S,4R)-2-[([[(1S,3R)-1,3-dicarboxybutyl]amino]carbonyl)amino]-4-methylpentanedioic acid | - |
Homo sapiens | |
(2S,4S)-2-[([[(1S,3S)-1,3-dicarboxybutyl]amino]carbonyl)amino]-4-methylpentanedioic acid | - |
Homo sapiens | |
(4S)-4-[([[(1S)-3-carboxy-1-(2H-tetrazol-5-yl)propyl]amino]carbonyl)amino]-4-(2H-tetrazol-5-yl)butanoic acid | - |
Homo sapiens | |
(S)-2-[3-((S)-1-carboxy-2-(4-hydroxyphenyl)ethyl)ureido]pentanedioic acid | - |
Homo sapiens | |
(S)-2-[3-((S)-1-carboxy-2-phenylethyl)ureido]pentanedioic acid | - |
Homo sapiens | |
(S)-2-[3-((S)-1-carboxy-3-(1H-tetrazol-5-yl)propyl)ureido]pentanedioic acid | - |
Homo sapiens | |
(S)-2-[3-((S)-1-carboxy-3-[1-(2-cyanoethyl)-1H-tetrazol-5-yl]propyl)ureido]pentanedioic acid | - |
Homo sapiens | |
(S)-2-[3-((S)-3-carboxy-1-(1H-tetrazol-5-yl)propyl)ureido]pentanedioic acid | - |
Homo sapiens | |
(S)-2-[3-((S)-3-carboxy-1-[1-(2-cyanoethyl)-1H-tetrazol-5-yl]propyl)ureido]pentanedioic acid | - |
Homo sapiens | |
(S)-2-[3-((S)-alpha-carboxy-4-hydroxybenzyl)ureido]pentanedioic acid | - |
Homo sapiens | |
(S)-2-[3-((S)-alpha-carboxybenzyl)ureido]pentanedioic acid | - |
Homo sapiens | |
(S)-2-[3-(S)-(1,3-dicarboxypropyl)ureido]pentanedioinc acid | - |
Homo sapiens | |
(S,S)-4,4'-bis[1-(2-cyanoethyl)-1H-tetrazol-5-yl]-2,2'-ureylenedibutyric acid | - |
Homo sapiens | |
(S,S)-4,4'-bis[1-(2-cyanoethyl)-1H-tetrazol-5-yl]-4,4'-ureylenedibutyric acid | - |
Homo sapiens | |
(S,S)-4,4'-di-(1H-tetrazol-5-yl)-2,2'-ureylenedibutyric acid | - |
Homo sapiens | |
(S,S)-4,4'-di-(1H-tetrazol-5-yl)-4,4'-ureylenedibutyric acid | - |
Homo sapiens | |
(S,S)-N,N'-carbonyl-2,2'-dimethyldiglutamic acid | - |
Homo sapiens | |
2-(phosphonomethyl)-pentanedioic acid | 2-PMPA | Homo sapiens | |
2-(phosphonomethyl)pentanedioic acid | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | type II transmembrane glycoprotein | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | Homo sapiens | - |
N-acetyl-alpha-L-aspartate + L-glutamate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | type II transmembrane glycoprotein | Homo sapiens |
Purification (Comment) | Organism |
---|---|
recombinant enzyme from CHO cells partially by membrane preparation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | - |
Homo sapiens | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | i.e. NAAG | Homo sapiens | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
N-acetyl-Asp-Glu + H2O | - |
Homo sapiens | N-acetyl-Asp + Glu | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCPII | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000009 | - |
(2S)-2-[([[(1S)-1-carboxy-3-(1H-tetrazol-5-yl)propyl]amino]carbonyl)amino]pentanedioic acid | pH 7.4, 37°C | Homo sapiens | |
0.0000009 | - |
(S)-2-[3-((S)-1-carboxy-3-(1H-tetrazol-5-yl)propyl)ureido]pentanedioic acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.0000014 | - |
2-(phosphonomethyl)pentanedioic acid | pH 7.4, 37°C | Homo sapiens | |
0.0000014 | - |
2-(phosphonomethyl)-pentanedioic acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.0000021 | - |
(S)-2-[3-((S)-alpha-carboxybenzyl)ureido]pentanedioic acid | pH 7.4, 37°C | Homo sapiens | |
0.0000021 | - |
(S)-2-[3-((S)-alpha-carboxybenzyl)ureido]pentanedioic acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.000003 | - |
(2S)-2-[([[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]carbonyl)amino]pentanedioic acid | pH 7.4, 37°C | Homo sapiens | |
0.000003 | - |
(S)-2-[3-((S)-1-carboxy-2-(4-hydroxyphenyl)ethyl)ureido]pentanedioic acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.0000053 | - |
(2S)-2-[[([(1S)-1-carboxy-3-[1-(2-cyanoethyl)-1H-tetrazol-5-yl]propyl]amino)carbonyl]amino]pentanedioic acid | pH 7.4, 37°C | Homo sapiens | |
0.0000053 | - |
(S)-2-[3-((S)-1-carboxy-3-[1-(2-cyanoethyl)-1H-tetrazol-5-yl]propyl)ureido]pentanedioic acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.0000059 | - |
(2S)-2-[([[(S)-carboxy(4-hydroxyphenyl)methyl]amino]carbonyl)amino]pentanedioic acid | pH 7.4, 37°C | Homo sapiens | |
0.0000059 | - |
(S)-2-[3-((S)-alpha-carboxy-4-hydroxybenzyl)ureido]pentanedioic acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.000008 | - |
(2S)-2-[([[(1S)-1,3-dicarboxypropyl]amino]carbonyl)amino]pentanedioic acid | pH 7.4, 37°C | Homo sapiens | |
0.000008 | - |
(S)-2-[3-(S)-(1,3-dicarboxypropyl)ureido]pentanedioinc acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.000012 | - |
(2S)-2-[([[(1S)-1-carboxy-2-phenylethyl]amino]carbonyl)amino]pentanedioic acid | pH 7.4, 37°C | Homo sapiens | |
0.000012 | - |
(S)-2-[3-((S)-1-carboxy-2-phenylethyl)ureido]pentanedioic acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.000014 | - |
(2S,2'S,4S)-N,N'-carbonyl-4-methyldiglutamic acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.0000144 | - |
(2S,2'S,4S)-N,N'-carbonyl-4-methyldiglutamic acid | pH 7.4, 37°C | Homo sapiens | |
0.0000149 | - |
(2S)-2-[([[(1S)-1-carboxy-3-(2H-tetrazol-5-yl)propyl]amino]carbonyl)amino]-4-(2H-tetrazol-5-yl)butanoic acid | pH 7.4, 37°C | Homo sapiens | |
0.0000149 | - |
N-[[(1S)-1-carboxy-3-(1H-tetrazol-5-yl)propyl]carbamoyl]-L-glutamic acid | pH 7.4, 37°C | Homo sapiens | |
0.000015 | - |
(S,S)-4,4'-di-(1H-tetrazol-5-yl)-2,2'-ureylenedibutyric acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.000095 | - |
(2S,2'S,4R)-4-benzyl-N,N'-carbonyldiglutamic acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.0000953 | - |
(2S,2'S,4R)-4-benzyl-N,N'-carbonyldiglutamic acid | pH 7.4, 37°C | Homo sapiens | |
0.000335 | - |
(2S)-2-[([[(1S)-3-carboxy-1-(2H-tetrazol-5-yl)propyl]amino]carbonyl)amino]pentanedioic acid | pH 7.4, 37°C | Homo sapiens | |
0.000335 | - |
(S)-2-[3-((S)-3-carboxy-1-(1H-tetrazol-5-yl)propyl)ureido]pentanedioic acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.000392 | - |
(2S,2'S,4R,4'R)-4,4'-dibenzyl-N,N'-carbonyldiglutamic acid | pH 7.4, 37°C | Homo sapiens | |
0.000392 | - |
(2S,2'S,4R,4'R)-4,4'-dibenzyl-N,N'-carbonyldiglutamic acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.000939 | - |
(S,S)-N,N'-carbonyl-2,2'-dimethyldiglutamic acid | pH 7.4, 37°C | Homo sapiens | |
0.000939 | - |
(S,S)-N,N'-carbonyl-2,2'-dimethyldiglutamic acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.001109 | - |
(2S,4S)-2-[([[(1S,3S)-1,3-dicarboxybutyl]amino]carbonyl)amino]-4-methylpentanedioic acid | pH 7.4, 37°C | Homo sapiens | |
0.00111 | - |
(2S,2'S,4S,4'S)-N,N'-carbonyl-4,4'-dimethyldiglutamic acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.001285 | - |
(2S,4R)-2-[([[(1S,3R)-1,3-dicarboxybutyl]amino]carbonyl)amino]-4-methylpentanedioic acid | pH 7.4, 37°C | Homo sapiens | |
0.00129 | - |
(2S,2'S,4R,4'R)-N,N'-carbonyl-4,4'-dimethyldiglutamic acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.00271 | - |
(S)-2-[3-((S)-3-carboxy-1-[1-(2-cyanoethyl)-1H-tetrazol-5-yl]propyl)ureido]pentanedioic acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.002711 | - |
(2S)-2-[[([(1S)-3-carboxy-1-[2-(2-cyanoethyl)-2H-tetrazol-5-yl]propyl]amino)carbonyl]amino]pentanedioic acid | pH 7.4, 37°C | Homo sapiens | |
0.004388 | - |
(4S)-4-[([[(1S)-3-carboxy-1-(2H-tetrazol-5-yl)propyl]amino]carbonyl)amino]-4-(2H-tetrazol-5-yl)butanoic acid | pH 7.4, 37°C | Homo sapiens | |
0.00439 | - |
(S,S)-4,4'-di-(1H-tetrazol-5-yl)-4,4'-ureylenedibutyric acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.00443 | - |
(S,S)-4,4'-bis[1-(2-cyanoethyl)-1H-tetrazol-5-yl]-2,2'-ureylenedibutyric acid | pH 7.4, 37°C, recombinant enzyme | Homo sapiens | |
0.004434 | - |
(S,S)-4,4'-bis[1-(2-cyanoethyl)-1H-tetrazol-5-yl]-2,2'-ureylenedibutyric acid | pH 7.4, 37°C | Homo sapiens | |
1 | - |
(S,S)-4,4'-bis[1-(2-cyanoethyl)-1H-tetrazol-5-yl]-4,4'-ureylenedibutyric acid | above, pH 7.4, 37°C, recombinant enzyme | Homo sapiens |