Literature summary for 3.4.17.21 extracted from

Jackson, P.F.; Slusher, B.S.
Design of NAALADase inhibitors: a novel neuroprotective strategy (2001), Curr. Med. Chem., 8, 949-957.

Search for more literature for 3.4.17.21

Inhibitors

Inhibitors	Comment	Organism	Structure
2-(3-hydroxybenzyl)-3-phosphonopropanoic acid	IC50: 508 nM	Rattus norvegicus
2-(phosphonomethyl)hexanoic acid	IC50: 185 nM	Rattus norvegicus
2-([hydroxy[3-(trifluoromethyl)benzyl]phosphoryl]methyl)pentanedioic acid	IC50: 55 nM	Rattus norvegicus
2-benzyl-3-phosphonopropanoic acid	IC50: 548 nM	Rattus norvegicus
2-[[(2-carboxy-4-phenylbutyl)(hydroxy)phosphoryl]methyl]pentanedioic acid	IC50: 2 nM	Rattus norvegicus
2-[[(2-carboxyethyl)(hydroxy)phosphoryl]methyl]pentanedioic acid	IC50: 1 nM	Rattus norvegicus
2-[[(3-fluorobenzyl)(hydroxy)phosphoryl]methyl]pentanedioic acid	IC50: 70 nM	Rattus norvegicus
2-[[(4-fluorobenzyl)(hydroxy)phosphoryl]methyl]pentanedioic acid	IC50: 64 nM	Rattus norvegicus
2-[[benzyl(hydroxy)phosphoryl]methyl]pentanedioic acid	IC50: 70 nM	Rattus norvegicus
2-[[hydroxy(2-phenylethyl)phosphoryl]methyl]pentanedioic acid	IC50: 150 nM	Rattus norvegicus
2-[[hydroxy(3-nitrobenzyl)phosphoryl]methyl]pentanedioic acid	IC50 59 nM	Rattus norvegicus
2-[[hydroxy(3-phenylpropyl)phosphoryl]methyl]pentanedioic acid	IC50: 230 nM	Rattus norvegicus
2-[[hydroxy(propyl)phosphoryl]methyl]pentanedioic acid	IC50: 560 nM	Rattus norvegicus
2-{[2-Carboxy-3-(4-methoxy-phenylamino)-propyl]-hydroxy-phosphinoylmethyl}-pentanedioic acid	IC50: 3 nM	Rattus norvegicus
4-phenyl-2-(phosphonomethyl)butanoic acid	IC50: 199 nM	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
N-acetyl-Asp-Glu + H2O	Rattus norvegicus	-	N-acetyl-Asp + Glu	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	stably expressed in CHO cells	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-acetyl-Asp-Glu + H2O	-	Rattus norvegicus	N-acetyl-Asp + Glu	-	?

Synonyms

Synonyms	Comment	Organism
NAALADase	-	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000001	-	IC50: 1 nM	Rattus norvegicus	2-[[(2-carboxyethyl)(hydroxy)phosphoryl]methyl]pentanedioic acid
0.000002	-	IC50: 2 nM	Rattus norvegicus	2-[[(2-carboxy-4-phenylbutyl)(hydroxy)phosphoryl]methyl]pentanedioic acid
0.000003	-	IC50: 3 nM	Rattus norvegicus	2-{[2-Carboxy-3-(4-methoxy-phenylamino)-propyl]-hydroxy-phosphinoylmethyl}-pentanedioic acid
0.000055	-	IC50: 55 nM	Rattus norvegicus	2-([hydroxy[3-(trifluoromethyl)benzyl]phosphoryl]methyl)pentanedioic acid
0.000059	-	IC50 59 nM	Rattus norvegicus	2-[[hydroxy(3-nitrobenzyl)phosphoryl]methyl]pentanedioic acid
0.000064	-	IC50: 64 nM	Rattus norvegicus	2-[[(4-fluorobenzyl)(hydroxy)phosphoryl]methyl]pentanedioic acid
0.00007	-	IC50: 70 nM	Rattus norvegicus	2-[[benzyl(hydroxy)phosphoryl]methyl]pentanedioic acid
0.00007	-	IC50: 70 nM	Rattus norvegicus	2-[[(3-fluorobenzyl)(hydroxy)phosphoryl]methyl]pentanedioic acid
0.00015	-	IC50: 150 nM	Rattus norvegicus	2-[[hydroxy(2-phenylethyl)phosphoryl]methyl]pentanedioic acid
0.000185	-	IC50: 185 nM	Rattus norvegicus	2-(phosphonomethyl)hexanoic acid
0.000199	-	IC50: 199 nM	Rattus norvegicus	4-phenyl-2-(phosphonomethyl)butanoic acid
0.00023	-	IC50: 230 nM	Rattus norvegicus	2-[[hydroxy(3-phenylpropyl)phosphoryl]methyl]pentanedioic acid
0.000508	-	IC50: 508 nM	Rattus norvegicus	2-(3-hydroxybenzyl)-3-phosphonopropanoic acid
0.000548	-	IC50: 548 nM	Rattus norvegicus	2-benzyl-3-phosphonopropanoic acid
0.00056	-	IC50: 560 nM	Rattus norvegicus	2-[[hydroxy(propyl)phosphoryl]methyl]pentanedioic acid

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Release 2023.1 (January 2023)