Any feedback?
Literature summary for 3.4.17.20 extracted from
- Carboxypeptidase U (TAFIa): a new drug target for fibrinolytic therapy? (2009), J. Thromb. Haemost., 7, 1962-1971.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| plasmin | - |
Homo sapiens | |
| thrombin | - |
Homo sapiens | |
| thrombin-thrombomodulin | - |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-(3-carbamimidamidophenyl)-3-sulfanylpropanoic acid | - |
Homo sapiens |  |
| 3-(6-aminopyridin-3-yl)-2-[1-(3-methylbutyl)-1H-imidazol-4-yl]propanoic acid | - |
Homo sapiens | |
| AZD-9684 | - |
Homo sapiens | |
| BX 528 | - |
Homo sapiens | |
| DL-2-mercapto methyl-3-guanidinoethyl-thiopropanoic acid | - |
Homo sapiens | |
| EF6265 | - |
Homo sapiens | |
| epsilon-amino caproic acid | - |
Homo sapiens | |
| guanidinoethyl-mercaptosuccinic acid | - |
Homo sapiens | |
| leech carboxypeptidase inhibitor | - |
Homo sapiens | |
| potato tuber carboxypeptidase inhibitor | competitive inhibition in the nanomolar range | Homo sapiens | |
| SAR-104772 | - |
Homo sapiens | |
| tick carboxypeptidase inhibitor | - |
Homo sapiens | |
| UK-396082 | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fibrin + H2O | Homo sapiens | - |
fibrin + L-Lys | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fibrin + H2O | - |
Homo sapiens | fibrin + L-Lys | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CPU | - |
Homo sapiens |
| TAFIa | - |
Homo sapiens |
| thrombin-activatable fibrinolysis inhibitor | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000002 | - |
- |
Homo sapiens | 3-(6-aminopyridin-3-yl)-2-[1-(3-methylbutyl)-1H-imidazol-4-yl]propanoic acid | |
| 0.000003 | - |
- |
Homo sapiens | 2-(3-carbamimidamidophenyl)-3-sulfanylpropanoic acid | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
