Literature summary for 3.4.17.20 extracted from

Fernandez, D.; Pallares, I.; Vendrell, J.; Aviles, F.X.
Progress in metallocarboxypeptidases and their small molecular weight inhibitors (2010), Biochimie, 93, 1484-1500.

Search for more literature for 3.4.17.20

Inhibitors

Inhibitors	Comment	Organism	Structure
(R)-2-(3-guanidinophenyl)-3-mercaptopropanoic acid	-	Homo sapiens
(R)-2-guanidino-3-mercaptopropanoic acid	-	Homo sapiens
(R)-3-(2-aminoethylthio)-2-(3-((R)-3-cyclohexyl-1-oxo-1-((1R,2R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylamino)propan-2-yl)ureido)propanoic acid	-	Homo sapiens
(S)-2,5-dihydroxy-N-(1-hydroxy-3-phenylpropan-2-yl)benzamide	-	Homo sapiens
2-(2-guanidinoethylthio)succinic acid	-	Homo sapiens
3-(2-guanidinoethylthio)-2-(mercaptomethyl)propanoic acid	-	Homo sapiens
3-(6-aminopyridin-3-yl)-2-(1-((5-(5-chlorothiophen-2-yl)isoxazol-3-yl)methyl)-1H-imidazol-4-yl)propanoic acid	-	Homo sapiens
3-(6-aminopyridin-3-yl)-2-(1-isopentyl-1H-imidazol-4-yl)propanoic acid	-	Homo sapiens
3-(6-aminopyridin-3-yl)-2-(mercaptomethyl)propanoic acid	-	Homo sapiens
anabaenopeptin-type cyclic peptide	-	Homo sapiens
BX-528	i.e. (S)-2-[3-(aminomethyl)phenyl]-3-hydroxy[(R)-2-methyl-1-[(3-phenylpropyl)sulfonyl]aminopropyl]phosphoryl propanoic acid	Homo sapiens
EF-6265	i.e. (2S)-7-amino-2-((hydroxyl((R)-2-methyl-1-(3-phenylpropanamido)propyl)phosphoryl)methyl)heptanoic acid	Homo sapiens
UK-396082	i.e. (S)-5-amino-2-((1-propyl-1H-imidazol-4-yl)methyl)pentanoic acid	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
60000	-	x * 60000	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
fibrin + H2O	Homo sapiens	-	fibrin + L-Lys	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	-	Homo sapiens	-
liver	CPU is secreted by the liver	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
fibrin + H2O	-	Homo sapiens	fibrin + L-Lys	-	?

Subunits

Subunits	Comment	Organism
?	x * 60000	Homo sapiens

Synonyms

Synonyms	Comment	Organism
CPU	-	Homo sapiens
TAFI	-	Homo sapiens
thrombin-activatable fibrinolysis inhibitor	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00001	-	UK-396082	-	Homo sapiens
0.00008	-	(R)-2-guanidino-3-mercaptopropanoic acid	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000007	-	-	Homo sapiens	(R)-3-(2-aminoethylthio)-2-(3-((R)-3-cyclohexyl-1-oxo-1-((1R,2R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylamino)propan-2-yl)ureido)propanoic acid
0.000002	-	-	Homo sapiens	3-(6-aminopyridin-3-yl)-2-(1-isopentyl-1H-imidazol-4-yl)propanoic acid
0.000002	-	-	Homo sapiens	BX-528
0.000003	-	-	Homo sapiens	(R)-2-(3-guanidinophenyl)-3-mercaptopropanoic acid
0.000004	-	-	Homo sapiens	3-(6-aminopyridin-3-yl)-2-(1-((5-(5-chlorothiophen-2-yl)isoxazol-3-yl)methyl)-1H-imidazol-4-yl)propanoic acid
0.0000083	-	-	Homo sapiens	EF-6265
0.0002	-	-	Homo sapiens	3-(6-aminopyridin-3-yl)-2-(mercaptomethyl)propanoic acid
0.0002	-	-	Homo sapiens	3-(2-guanidinoethylthio)-2-(mercaptomethyl)propanoic acid
0.0002	-	-	Homo sapiens	anabaenopeptin-type cyclic peptide
0.0044	-	-	Homo sapiens	2-(2-guanidinoethylthio)succinic acid
0.044	-	-	Homo sapiens	(S)-2,5-dihydroxy-N-(1-hydroxy-3-phenylpropan-2-yl)benzamide

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Release 2023.1 (January 2023)