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Literature summary for 3.4.17.20 extracted from

  • Heylen, E.; Van Goethem, S.; Willemse, J.; Olsson, T.; Augustyns, K.; Hendriks, D.
    Development of a sensitive and selective assay for the determination of procarboxypeptidase U (thrombin-activatable fibrinolysis inhibitor) in plasma (2010), Anal. Biochem., 396, 152-154.
    View publication on PubMed
Search for more literature for 3.4.17.20

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
 N-benzoyl-2'-cyano-L-Phe-L-Arg in 50 mM HEPES (pH 8.0) at 25°C Homo sapiens
0.84
-
 N-benzoyl-Gly-L-Arg in 50 mM HEPES (pH 8.0) at 25°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma CPU circulates in plasma as an inactive precursor, designated procarboxypeptidase U (proCPU or TAFI) from which it is released after activation by thrombin, plasmin, or the thrombin-thrombomodulin complex Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Hippuryl-L-Arg + H2O
-
 Homo sapiens Hippuric acid + L-Arg
-
 ?
N-benzoyl-2'-cyano-L-Phe-L-Arg + H2O selective CPU substrate Homo sapiens N-benzoyl-2'-cyano-L-Phe + L-Arg
-
 ?
N-benzoyl-Gly-L-Arg + H2O
-
 Homo sapiens N-benzoyl-Gly + L-Arg
-
 ?

Synonyms

Synonyms Comment Organism
activated thrombin-activatable fibrinolysis inhibitor
-
 Homo sapiens
TAFIa
-
 Homo sapiens
thrombin-activatable fibrinolysis inhibitor
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
59
-
 N-benzoyl-2'-cyano-L-Phe-L-Arg in 50 mM HEPES (pH 8.0) at 25°C Homo sapiens
64
-
 N-benzoyl-Gly-L-Arg in 50 mM HEPES (pH 8.0) at 25°C Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
76
-
 N-benzoyl-Gly-L-Arg in 50 mM HEPES (pH 8.0) at 25°C Homo sapiens
2950
-
 N-benzoyl-2'-cyano-L-Phe-L-Arg in 50 mM HEPES (pH 8.0) at 25°C Homo sapiens