Activating Compound | Comment | Organism | Structure |
---|---|---|---|
factor VIII | TAFI activation increases in plasma as the concentration of factor VIII increases | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | the extent of TAFI activation over time in normal plasma and factor VIII deficient plasma (FVIII-DP) is analysed and it is determined whether soluble thrombomodulin can correct the lysis defect in factor VIII deficient plasma. TAFI activation increases as the concentration of factor VIII increases. Factor VIII at a level of 10% fully corrects the lysis defect in spite of the extent of TAFI activation being only one half that obtained with 100% factor VIII. In addition, thrombomodulin increases TAFI activation sufficiently to correct the premature lysis defect in factor VIII-deficient plasma | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
TAFI | - |
Homo sapiens |
thrombin-activatable fibrinolysis inhibitor | - |
Homo sapiens |