Literature summary for 3.4.17.20 extracted from

Erem, C.; Ucuncu, O.; Yilmaz, M.; Kocak, M.; Nuhoglu, I.; Ersoz, H.O.
Increased thrombin-activatable fibrinolysis inhibitor and decreased tissue factor pathway inhibitor in patients with hypothyroidism (2009), Endocrine, 35, 75-80.

Search for more literature for 3.4.17.20

Application

Application	Comment	Organism
medicine	important differences in the hemostatic parameters between the patients with hypothyroidism and healthy controls are found. Increased FVII, TM, and TAFI and decreased FV, FVIII, vWF, protein C, protein S, and TFPI in these patients represent a potential hypercoagulable and hypofibrinolytic state, possible endothelial dysfunction, which might augment the risk for atherosclerotic and atherothrombotic complications in patients with hypothyroidism	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	coagulation and fibrinolytic parameters including TAFI and TFPI are assessed in patients with hypothyroidism: Factors V, VII, VIII activities, von Willebrand factor, protein C, protein S, thrombomodulin, TFPI, and TAFI are measured. Compared with the control subjects, factor VII activity, and thrombomodulin Ag and TAFI Ag levels are significantly increased in patients with hypothyroidism, whereas FV, FVIII, vWF, protein C and protein S activities, and TFPI Ag levels are significantly decreased	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
TFAI	-	Homo sapiens
thrombin-activatable fibrinolysis inhibitor	-	Homo sapiens

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Release 2023.1 (January 2023)