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Literature summary for 3.4.17.20 extracted from

  • Matus, V.; Willemse, J.; Quiroga, T.; Goycoolea, M.; Aranda, E.; Panes, O.; Pereira, J.; Hendriks, D.; Mezzano, D.
    Procarboxypeptidase U (TAFI) and the Thr325Ile proCPU polymorphism in patients with hereditary mucocutaneous hemorrhages (2009), Clin. Chim. Acta, 401, 158-161.
    View publication on PubMed

Application

Application Comment Organism
medicine the proCPU system is not of major importance in the bleeding pathogenesis of these patients. The higher proCPU levels in the patients may even modestly counteract the bleeding tendency Homo sapiens

Protein Variants

Protein Variants Comment Organism
T325I distribution of the Thr325Ile proCPU polymorphism in 193 patients with mucocutaneous bleeding of whom 116 are bleeders of unknown cause , and in 143 healthy, age and sex-matched controls is analyzed. ProCPU concentration is higher in women than in men, increases with age, and is significantly correlated with clot lysis time, platelet count, APTT, and PT. proCPU levels are unexpectedly higher in patients than in controls. The allele distribution of the Thr325Ile proCPU polymorphism is similar in both groups, with a low percentage of homozygous Ile/Ile Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
procarboxypeptidase U
-
Homo sapiens
proCPU
-
Homo sapiens