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Literature summary for 3.4.17.20 extracted from

  • Marx P. , M.P.; Meijers J. C. , M.J.
    Mechanism of action of carboxypeptidase U: staying above the threshold (2004), J. Thromb. Haemost., 2, 414-415.
    View publication on PubMed
Search for more literature for 3.4.17.20

Protein Variants

Protein Variants Comment Organism
T325I naturally occurring mutant showing a twofold increased stability compared to the wild-type enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is involved in the regulation of the coagulation and fibrinolytic systems preventing blood loss at sites of vessel wall damage and maintainthe fluidity of the blood in the body ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification ProCPU is activated by thrombin or plasmin, the reaction is highly enhanced by thrombomodulin and glycosaminoglycans Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
release of C-terminal Arg and Lys from a polypeptide reaction mechanism Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in the regulation of the coagulation and fibrinolytic systems preventing blood loss at sites of vessel wall damage and maintainthe fluidity of the blood in the body Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
activated thrombin-activatable fibrinolysis inhibitor
-
 Homo sapiens
Carboxypeptidase R
-
 Homo sapiens
carboxypeptidase U
-
 Homo sapiens
CPU
-
 Homo sapiens
Plasma carboxypeptidase B
-
 Homo sapiens