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Literature summary for 3.4.17.20 extracted from
- Activation and characterization of procarboxypeptidase B from human plasma (1995), Biochemistry, 34, 5811-5816.
General Stability
| General Stability | Organism |
|---|---|
| proteolytic cleavage at Arg330 and subsequent inactivation can be diminished by the addition of 6-aminohexanoic acid, 5-aminopentanoic acid, 7-aminoheptanoic acid, hippuryl-L-Lys, hippuryl-L-Arg, L-Arg, or L-Lys | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 10 | - |
bradykinin | - |
Homo sapiens |  |
| 63 | - |
Arg6-Leu5-enkephalin | - |
Homo sapiens | |
| 110 | - |
Lys6-Leu5-enkephalin | - |
Homo sapiens | |
| 140 | - |
Arg6-Met5-enkephalin | - |
Homo sapiens | |
| 180 | - |
hippuryl-L-Arg | - |
Homo sapiens | |
| 210 | - |
N-[3-(2-Furylacryloyl)]-L-Ala-L-Arg | - |
Homo sapiens | |
| 220 | - |
Lys6-Met5-enkephalin | - |
Homo sapiens | |
| 240 | - |
Hippuryl-L-argininic acid | - |
Homo sapiens | |
| 270 | - |
Hippuryl-L-Lys | - |
Homo sapiens | |
| 280 | - |
N-[3-(2-Furylacryloyl)]-L-Ala-L-Lys | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | metalloproteinase | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Arg6-Leu5-enkephalin + H2O | i.e. Tyr-Gly-Gly-Phe-Leu-Arg | Homo sapiens | Tyr-Gly-Gly-Phe-Leu + Arg | - |
? | |
| Arg6-Met5-enkephalin + H2O | i.e. Tyr-Gly-Gly-Phe-Met-Arg | Homo sapiens | Tyr-Gly-Gly-Phe-Met + Arg | - |
? | |
| bradykinin + H2O | i.e. Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg | Homo sapiens | Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + Arg | - |
? | |
| Hippuryl-L-Arg + H2O | - |
Homo sapiens | Hippuric acid + L-Arg | - |
? | |
| Hippuryl-L-argininic acid + H2O | - |
Homo sapiens | Hippuric acid + argininic acid | - |
? | |
| Hippuryl-L-Lys + H2O | - |
Homo sapiens | Hippuric acid + L-Lys | - |
? | |
| Lys6-Leu5-enkephalin + H2O | i.e. Tyr-Gly-Gly-Phe-Leu-Lys | Homo sapiens | Tyr-Gly-Gly-Phe-Leu + Lys | - |
? | |
| Lys6-Met5-enkephalin + H2O | i.e. Tyr-Gly-Gly-Phe-Met-Lys | Homo sapiens | Tyr-Gly-Gly-Phe-Met + Lys | - |
? | |
| N-[3-(2-Furylacryloyl)]-L-Ala-L-Arg + H2O | - |
Homo sapiens | N-[3-(2-Furylacryloyl)]-L-Ala + L-Arg | - |
? | |
| N-[3-(2-Furylacryloyl)]-L-Ala-L-Lys + H2O | - |
Homo sapiens | N-[3-(2-Furylacryloyl)]-L-Ala + L-Lys | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 15 | - |
Hippuryl-L-Lys | - |
Homo sapiens | |
| 26 | - |
hippuryl-L-Arg | - |
Homo sapiens | |
| 29 | - |
N-[3-(2-Furylacryloyl)]-L-Ala-L-Lys | - |
Homo sapiens | |
| 36 | - |
N-[3-(2-Furylacryloyl)]-L-Ala-L-Arg | - |
Homo sapiens | |
| 121 | - |
bradykinin | - |
Homo sapiens | |
| 169 | - |
Hippuryl-L-argininic acid | - |
Homo sapiens | |
| 282 | - |
Lys6-Leu5-enkephalin | - |
Homo sapiens | |
| 290 | - |
Lys6-Met5-enkephalin | - |
Homo sapiens | |
| 647 | - |
Arg6-Met5-enkephalin | - |
Homo sapiens | |
| 748 | - |
Arg6-Leu5-enkephalin | - |
Homo sapiens | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 9 | ester substrates | Homo sapiens |
| 7.5 | 8 | peptide substrates | Homo sapiens |
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