Literature summary for 3.4.17.15 extracted from

Jitonnom, J.; Sontag, C.
Comparative study on activation mechanism of carboxypeptidase A1, A2 and B: first insights from steered molecular dynamics simulations (2012), J. Mol. Graph. Model., 38, 298-303.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P48052	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	in silico conversion of zymogen into the primary cleavage state using available X-ray structures to investigate its spontaneous dissociation process of the prosegment from its associated enzyme domain using steered molecular dynamics simulation. The cleavage substantially destabilizes most of the hydrogen bonds at the prosegment-enzyme interface. During prosegment unbinding, the enzyme shows first rupture in the globular domain and then in the connecting segment	Homo sapiens

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Release 2023.1 (January 2023)