Cloned (Comment) | Organism |
---|---|
procarboxypeptidase A2 is expressed in Pichia pastoris | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
hanging drop vapour diffusion method at 4°C and at 20°C, procarboxypeptidase A2 is crystallized using vapour diffusion approach. The crystals belong to the monoclinic system spacegroup P21 and present one procarboxypeptidase A2 molecule per asymmetric unit | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.125 | - |
benzyloxycarbonyl-Gly-Gly-Tyr | pH 7.5, 25°C | Homo sapiens | |
0.146 | - |
benzyloxycarbonyl-Gly-Gly-Trp | pH 7.5, 25°C | Homo sapiens | |
0.175 | - |
Benzyloxycarbonyl-Gly-Tyr | pH 7.5, 25°C | Homo sapiens | |
0.261 | - |
benzyloxycarbonyl-Gly-Trp | pH 7.5, 25°C | Homo sapiens | |
0.372 | - |
benzyloxycarbonyl-Gly-Gly-Phe | pH 7.5, 25°C | Homo sapiens | |
2.028 | - |
benzyloxycarbonyl-Gly-Trp | pH 7.5, 25°C | Homo sapiens | |
2.27 | - |
Benzyloxycarbonyl-Gly-Phe | pH 7.5, 25°C | Homo sapiens | |
5.3 | - |
benzyloxycarbonyl-Gly-Gly-Leu | pH 7.5, 25°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | synthesized as procarboxypeptidase A2 | Homo sapiens |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreas | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-Gly-Gly-Leu + H2O | - |
Homo sapiens | ? | - |
? | |
benzyloxycarbonyl-Gly-Gly-Phe + H2O | - |
Homo sapiens | ? | - |
? | |
benzyloxycarbonyl-Gly-Gly-Trp + H2O | - |
Homo sapiens | ? | - |
? | |
benzyloxycarbonyl-Gly-Gly-Tyr + H2O | - |
Homo sapiens | ? | - |
? | |
benzyloxycarbonyl-Gly-Phe + H2O | - |
Homo sapiens | ? | - |
? | |
benzyloxycarbonyl-Gly-Trp + H2O | - |
Homo sapiens | ? | - |
? | |
benzyloxycarbonyl-Gly-Tyr + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | no measurable activity with benzyloxycarbonyl-Gly-Gly-Val, benzyloxycarbonyl-Gly-Gly-Ala und benzyloxycarbonyl-Gly-Gly-Ser. CPA2 is the only reported carboxypeptidase with specificity for C-terminal Trp residues | Homo sapiens | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
9.7 | - |
Benzyloxycarbonyl-Gly-Tyr | pH 7.5, 25°C | Homo sapiens | |
11.8 | - |
benzyloxycarbonyl-Gly-Gly-Leu | pH 7.5, 25°C | Homo sapiens | |
16.1 | - |
Benzyloxycarbonyl-Gly-Phe | pH 7.5, 25°C | Homo sapiens | |
58.1 | - |
benzyloxycarbonyl-Gly-Gly-Phe | pH 7.5, 25°C | Homo sapiens | |
70 | - |
benzyloxycarbonyl-Gly-Gly-Tyr | pH 7.5, 25°C | Homo sapiens | |
90.3 | - |
benzyloxycarbonyl-Gly-Gly-Phe | pH 7.5, 25°C | Homo sapiens |