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Literature summary for 3.4.17.13 extracted from

  • Baum, E.Z.; Crespo-Carbone, S.M.; Foleno, B.; Peng, S.; Hilliard, J.J.; Abbanat, D.; Goldschmidt, R.; Bush, K.
    Identification of a dithiazoline inhibitor of Escherichia coli L,D-carboxypeptidase A (2005), Antimicrob. Agents Chemother., 49, 4500-4507.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.17.13

Cloned(Commentary)

Cloned (Comment) Organism
gene ldcA, cloning from genomic DNA of strain MG1655, DNA and amino acid sequence determination and analysis Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
(3Z)-3-[(3-ethoxypropyl)imino]-N,N-diethyl-3H-1,2,4-dithiazol-5-amine i.e. DTZ, a dithiazoline inhibitor, specificity, overview, the compound has slight antibacterial activity against strain MG1655 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli the enzyme is involved in cell wall synthesis ?
-
 ?
additional information Escherichia coli MG1655 the enzyme is involved in cell wall synthesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 gene ldcA
-
Escherichia coli MG1655
-
 gene ldcA
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala-gamma-D-Glu-L-Lys-D-Ala + H2O
-
 Escherichia coli ?
-
 ?
L-Ala-gamma-D-Glu-L-Lys-D-Ala + H2O
-
 Escherichia coli MG1655 ?
-
 ?
additional information the enzyme is involved in cell wall synthesis Escherichia coli ?
-
 ?
additional information the enzyme is specific for D-Ala and requires a substrate chain length of 4 monomers, no or poor activity with L-Ala-gamma-D-Glu-L-Lys-L-Ala, D-Glu-L-Lys-D-Ala and L-Lys-D-Ala Escherichia coli ?
-
 ?
additional information the enzyme is involved in cell wall synthesis Escherichia coli MG1655 ?
-
 ?
additional information the enzyme is specific for D-Ala and requires a substrate chain length of 4 monomers, no or poor activity with L-Ala-gamma-D-Glu-L-Lys-L-Ala, D-Glu-L-Lys-D-Ala and L-Lys-D-Ala Escherichia coli MG1655 ?
-
 ?

Synonyms

Synonyms Comment Organism
L,D-carboxypeptidase A
-
 Escherichia coli
LdcA
-
 Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
 assay at Escherichia coli