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Literature summary for 3.4.17.12 extracted from
- Carboxypeptidase M: Multiple alliances and unknown partners (2009), Clin. Chim. Acta, 399, 24-39.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | patients with chronic persistent atrial fibrillation have reduced amounts of CPM mRNA and protein in the atrial tissue | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HEK-293 cells, in Pichia pastoris, and in baculovirus-infected insect cells | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E264Q | the mutation completely eliminates the CPM activity | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Homo sapiens |  |
| 1,4-dithiothreitol | - |
Homo sapiens | |
| 2-Guanidinoethylmercaptosuccinic acid | strong CPM inhibitor | Homo sapiens | |
| 2-mercaptomethyl-3-guanidinoethyl thiopropanoic acid | strong CPM inhibitor | Homo sapiens | |
| Cd2+ | - |
Homo sapiens | |
| Co2+ | - |
Homo sapiens | |
| EDTA | - |
Homo sapiens | |
| Zn2+ | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | the catalytic center is located in the catalytic domain in a cavity with a funnel-like access that contains the catalytic Zn2+ ion | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 48000 | - |
deglycosylated protein, calculated from amino acid sequence | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | using small substrates of the form benzoyl-Xaa-Arg CPM has the highest catalytic efficiency for substrates with the nonpolar aliphatic residues Ala and Met and aromatic amino acids (Phe, Tyr, Trp) in the penultimate place and the lowest with branched side chains (Ile) | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P14384 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipocyte | - |
Homo sapiens | - |
| alveolar cell type I | - |
Homo sapiens | - |
| alveolar macrophage | - |
Homo sapiens | - |
| B-lymphocyte | - |
Homo sapiens | - |
| brain | - |
Homo sapiens | - |
| bronchoalveolar lavage fluid | - |
Homo sapiens | - |
| central nervous system | - |
Homo sapiens | - |
| chondrocyte | - |
Homo sapiens | - |
| dendritic cell | - |
Homo sapiens | - |
| endothelial cell | - |
Homo sapiens | - |
| epithelial cell | - |
Homo sapiens | - |
| fibroblast | very low activity | Homo sapiens | - |
| gastrointestinal tract | - |
Homo sapiens | - |
| glomerular mesangial cell | - |
Homo sapiens | - |
| granulocyte | - |
Homo sapiens | - |
| heart | CPM mRNA expression is very low in the human heart | Homo sapiens | - |
| hematopoietic cell | - |
Homo sapiens | - |
| kidney | CPM expression is the highest in kidneys | Homo sapiens | - |
| liver | CPM mRNA expression is very low in the human liver | Homo sapiens | - |
| lung | CPM expression is the highest in lung membrane fractions | Homo sapiens | - |
| macrophage | CPM expression is the highest in macrophages | Homo sapiens | - |
| mesenchymal cell | - |
Homo sapiens | - |
| mesenchymal stem cell | - |
Homo sapiens | - |
| osteoblast | - |
Homo sapiens | - |
| osteosarcoma cell | - |
Homo sapiens | - |
| pancreas | CPM mRNA expression is very low in the human pancreas | Homo sapiens | - |
| peripheral nervous system | - |
Homo sapiens | - |
| placenta | CPM expression is the highest in placenta | Homo sapiens | - |
| pulmonary artery endothelial cell | - |
Homo sapiens | - |
| seminal plasma | - |
Homo sapiens | - |
| skeletal muscle | very low activity | Homo sapiens | - |
| T-lymphocyte | - |
Homo sapiens | - |
| U2-OS cell | - |
Homo sapiens | - |
| urine | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzoyl-Gly-argininic acid + H2O | - |
Homo sapiens | benzoyl-Gly + argininic acid | - |
? | |
| benzoyl-Gly-L-Arg + H2O | - |
Homo sapiens | benzoyl-Gly + L-Arg | - |
? | |
| benzoyl-L-Asn-L-Arg + H2O | - |
Homo sapiens | benzoyl-L-Asn + L-Arg | - |
? | |
| dansyl-L-Ala-L-Arg + H2O | - |
Homo sapiens | dansyl-L-Ala + L-Arg | - |
? | |
| Hippuryl-L-Lys + H2O | - |
Homo sapiens | Hippuric acid + L-Lys | - |
? | |
| additional information | using small substrates of the form benzoyl-Xaa-Arg CPM has the highest catalytic efficiency for substrates with the nonpolar aliphatic residues Ala and Met and aromatic amino acids (Phe, Tyr, Trp) in the penultimate place and the lowest with branched side chains (Ile) | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 48000, X-ray crystallography | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CPM | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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