Application | Comment | Organism |
---|---|---|
medicine | potential use in antibody directed enzyme prodrug therapy (ADEPT) | Pseudomonas sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
diethylstilbestrol-glutamate + H2O | Pseudomonas sp. | the water soluble substrate can be used as a prodrug that is hydrolyzed to yield the active drug in an antibody directed enzyme prodrug therapy | diethylstilbestrol + L-glutamate | - |
? | |
additional information | Pseudomonas sp. | specifically cleaves terminal glutamic acid amines | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas sp. | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
diethylstilbestrol-glutamate + H2O | - |
Pseudomonas sp. | diethylstilbestrol + L-glutamate | - |
? | |
diethylstilbestrol-glutamate + H2O | the water soluble substrate can be used as a prodrug that is hydrolyzed to yield the active drug in an antibody directed enzyme prodrug therapy | Pseudomonas sp. | diethylstilbestrol + L-glutamate | - |
? | |
additional information | specifically cleaves terminal glutamic acid amines | Pseudomonas sp. | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carboxypeptidase G2 | - |
Pseudomonas sp. |
CPG2 | - |
Pseudomonas sp. |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Pseudomonas sp. |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7.3 | - |
assay at | Pseudomonas sp. |