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Literature summary for 3.4.17.11 extracted from
- Interactions of carboxypeptidase G2 with 6S-leucovorin and 6R-leucovorin in vitro: implications for the application in case of methotrexate intoxications (2005), Cancer Chemother. Pharmacol., 55, 347-353.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (6R,S)-leucovorin + H2O | Homo sapiens | inactivation of the antitumor drug | N-(6R,S)-5-formyl-5,6,7,8-tetrahydropteroic acid + L-glutamate | - |
? | |
| 7-hydroxy-methotrexate + H2O | Homo sapiens | - |
7-hydroxy-4-amino-4-deoxy-N10-methylpteroic acid + L-glutamate | - |
? | |
| methotrexate + H2O | Homo sapiens | highly reduced clearance of the drug in enzyme-defective patients leads to severe neutropenia, mucositis, nephrotoxicity, neurotoxicity, and elevation of liver enzymes in plasma | 4-amino-4-deoxy-N10-methylpteroic acid + L-glutamate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (6R,S)-leucovorin + H2O | inactivation of the antitumor drug | Homo sapiens | N-(6R,S)-5-formyl-5,6,7,8-tetrahydropteroic acid + L-glutamate | - |
? | |
| (6R,S)-leucovorin + H2O | the pharmacolically active 6S-stereoisomer is degraded faster than the inactive 6R-stereoisomer | Homo sapiens | N-(6R,S)-5-formyl-5,6,7,8-tetrahydropteroic acid + L-glutamate | - |
? | |
| 7-hydroxy-methotrexate + H2O | - |
Homo sapiens | 7-hydroxy-4-amino-4-deoxy-N10-methylpteroic acid + L-glutamate | - |
? | |
| methotrexate + H2O | - |
Homo sapiens | 4-amino-4-deoxy-N10-methylpteroic acid + L-glutamate | - |
? | |
| methotrexate + H2O | highly reduced clearance of the drug in enzyme-defective patients leads to severe neutropenia, mucositis, nephrotoxicity, neurotoxicity, and elevation of liver enzymes in plasma | Homo sapiens | 4-amino-4-deoxy-N10-methylpteroic acid + L-glutamate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| carboxypeptidase G2 | - |
Homo sapiens |
| CPG2 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.3 | - |
assay at | Homo sapiens |
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