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Literature summary for 3.4.17.11 extracted from

  • Buchen, S.; Ngampolo, D.; Melton, R.G.; Hasan, C.; Zoubek, A.; Henze, G.; Bode, U.; Fleischhack, G.
    Carboxypeptidase G2 rescue in patients with methotrexate intoxication and renal failure (2005), Br. J. Cancer, 92, 480-487.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.17.11

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methotrexate + H2O Pseudomonas sp. related toxicity, overview, rapid inactivation of methotrexate by CPDG2, the product DAMPA is eliminated more raoidly than methotrexate 4-[(2,4-diamino-6-(pteridinyl)methyl)-methylamino]-benzoic acid + L-glutamate i.e. DAMPA ?
additional information Pseudomonas sp. effects of carboxypeptidase G2 administration to patients with methotrexate-induce renal failure, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas sp.
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation recombinant enzyme Pseudomonas sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6R,S)-leucovorin + H2O
-
 Pseudomonas sp. N-(6R,S)-5-formyl-5,6,7,8-tetrahydropteroic acid + L-glutamate
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 ?
methotrexate + H2O
-
 Pseudomonas sp. 4-[(2,4-diamino-6-(pteridinyl)methyl)-methylamino]-benzoic acid + L-glutamate
-
 ?
methotrexate + H2O related toxicity, overview, rapid inactivation of methotrexate by CPDG2, the product DAMPA is eliminated more raoidly than methotrexate Pseudomonas sp. 4-[(2,4-diamino-6-(pteridinyl)methyl)-methylamino]-benzoic acid + L-glutamate i.e. DAMPA ?
additional information effects of carboxypeptidase G2 administration to patients with methotrexate-induce renal failure, overview Pseudomonas sp. ?
-
 ?

Synonyms

Synonyms Comment Organism
carboxypeptidase G2
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 Pseudomonas sp.
CPDG2
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 Pseudomonas sp.