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Literature summary for 3.4.17.10 extracted from
- The sorting of proglucagon to secretory granules is mediated by carboxypeptidase E and intrinsic sorting signals (2013), J. Endocrinol., 217, 229-240.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Neuro-2a cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| carboxypeptidase E | - |
Homo sapiens |
| CPE | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | in Neuro 2a cells that lack CPE, PC1/3 and PC2, proglucagon co-localise with the Golgi marker p115 as determined by quantitative immunofluorescence microscopy. siRNA-mediated knockdown of CPE disrupts regulated secretion of glucagon from pancreatic-derived alphaTC1-6 cells, but not of GLP-1 from intestinal cell-derived GLUTag cells | Homo sapiens |
| physiological function | sorting of proglucagon to secretory granules is mediated by carboxypeptidase E | Homo sapiens |
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Release 2023.1 (January 2023)
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