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Literature summary for 3.4.17.10 extracted from

  • Oiso, S.; Takeda, Y.; Futagawa, T.; Miura, T.; Kuchiiwa, S.; Nishida, K.; Ikeda, R.; Kariyazono, H.; Watanabe, K.; Yamada, K.
    Contactin-associated protein (Caspr) 2 interacts with carboxypeptidase E in the CNS (2009), J. Neurochem., 109, 158-167.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Synonyms

Synonyms Comment Organism
carboxypeptidase E
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Homo sapiens
CPE
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Homo sapiens

General Information

General Information Comment Organism
physiological function glutathione S-transferase pull-down and immunoprecipitation analyses indicate that contactin-associated protein 2 is associated with carboxypeptidase E in vitro and in vivo. Both contactin-associated protein 2 and carboxypeptidase E are expressed predominantly in the CNS. Immunohistochemical analysis reveals that both contactin-associated protein 2- and carboxypeptidase E-like immunoreactivities are found to co-localize in the apical dendrites and cell bodies of rat cortical neurons. In subcellular localization analysis, contactin-associated protein 2- and carboxypeptidase E-like immunoreactivities are co-migrated in the fractions of Golgi/ER. The membrane-bound form of carboxypeptidase E functions as a sorting receptor of prohormones in the trans-Golgi network. Carboxypeptidase E may be a key molecule to regulate contactin-associated protein 2 trafficking to the cell membrane Homo sapiens