Literature summary for 3.4.17.1 extracted from

Reynolds, D.S.; Gurley, D.S.; Austen, K.F.
Cloning and characterization of the novel gene for mast cell carboxypeptidase A (1992), J. Clin. Invest., 89, 273-282.

Search for more literature for 3.4.17.1

Application

Application	Comment	Organism
analysis	the enzyme can serve as specific molecular maker for mast cells amongst normal hematopoietic cell populations	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
DNA and amino acid sequence determination and analysis, the gene contains 11 exons and is located on chromosome 3, genetic organization, phylogenetic analysis	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
secretory granule	-	Homo sapiens	30141	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	zinc metallopeptidase, binding site	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15088	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HL-60 cell	low expression level	Homo sapiens	-
KG-1 cell	low expression level	Homo sapiens	-
lung	high expression level	Homo sapiens	-
lung	high expression level, dispersed lung cells enriched for mast cells	Homo sapiens	-
mast cell	-	Homo sapiens	-
additional information	MC-CPA expression analysis, overview	Homo sapiens	-
skin	low expression level	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is a secretory granule metalloexopeptidase, MC-CPA is unique among carboxypeptidases inthaving a CPA-like substrate-binding pocket and enzymatic activity despite overall protein and gene structures more similar to CPB	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
Carboxypeptidase A3	-	Homo sapiens
CPA3	-	Homo sapiens
mast cell carboxypeptidase A	-	Homo sapiens
MC-CPA	-	Homo sapiens

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Release 2023.1 (January 2023)