Literature summary for 3.4.16.5 extracted from

Petrera, A.; Kern, U.; Linz, D.; Gomez-Auli, A.; Hohl, M.; Gassenhuber, J.; Sadowski, T.; Schilling, O.
Proteomic profiling of cardiomyocyte-specific cathepsin A overexpression links cathepsin A to the oxidative stress response (2016), J. Proteome Res., 15, 3188-3195 .

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Cloned(Commentary)

Cloned (Comment)	Organism
overexpression in mouse and rat cardiomyocytes	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P10619	-	-

Synonyms

Synonyms	Comment	Organism
CTSA	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	mouse model of cardiomyocyte-specific human CTSA overexpression. CTSA strongly impairs the balance of the proteolytic system by upregulating proteases such as cathepsin B, cathepsin D, and cathepsin Z while downregulating numerous protease inhibitors. Cardiomyocyte-specific human CTSA overexpression strongly reduces the levels of numerous antioxidative stress proteins, i.e., peroxiredoxins and protein deglycase DJ-1. In vitro, using cultured rat cardiomyocytes, ectopic overexpression of CTSA results in accumulation of reactive oxygen species	Homo sapiens

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Release 2023.1 (January 2023)