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Literature summary for 3.4.16.5 extracted from

  • Pan, X.; Grigoryeva, L.; Seyrantepe, V.; Peng, J.; Kollmann, K.; Tremblay, J.; Lavoie, J.; Hinek, A.; Lübke, T.; Pshezhetsky, A.
    Serine carboxypeptidase SCPEP1 and cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of Endothelin-1 (2014), PLoS Genet., 10, e1004146.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus Scpep1 has carboxypeptidase activity against endothelin ET-1 ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Scpep1 has carboxypeptidase activity against endothelin ET-1 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
Scpep1
-
 Mus musculus
serine carboxypeptidase
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 Mus musculus

General Information

General Information Comment Organism
malfunction mice with a double CathA/Scpep1 deficiency (DD mice) demonstrate hypertension, increased ET-1-induced vasoconstriction and prolonged half-life of circulating ET-1 as compared to both wild-type animals and those with single CathA or Scpep1 deficiencies Mus musculus
physiological function SCEP1 complements CathA action towards endothelin ET-1 Mus musculus
physiological function Scpep1 and CathA together participate in the control of endothelin ET-1 regulation of vascular tone and hemodynamics Mus musculus