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Literature summary for 3.4.16.5 extracted from

  • Bonten, E.J.; Campos, Y.; Zaitsev, V.; Nourse, A.; Waddell, B.; Lewis, W.; Taylor, G.; dAzzo, A.
    Heterodimerization of the sialidase NEU1 with the chaperone protective protein/cathepsin A prevents its premature oligomerization (2009), J. Biol. Chem., 284, 28430-28441.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.16.5

Cloned(Commentary)

Cloned (Comment) Organism
expressed in insect cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
A251E the mutant shows increased activity compared to the wild type cathepsin A Homo sapiens
K355Q the mutant shows increased activity compared to the wild type cathepsin A Homo sapiens
L354D the mutant shows decreased activity compared to the wild type cathepsin A Homo sapiens
P451A the mutant shows increased activity compared to the wild type cathepsin A Homo sapiens
R20A the mutant shows decreased activity compared to the wild type cathepsin A Homo sapiens
W382A the mutant shows decreased activity compared to the wild type cathepsin A Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
 mature enzyme, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P10619
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lysosomal neuraminidase-1 + H2O lysosomal neuraminidase-1 gains full catalytic activity in the lysosome through its binding to PPCA Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PpcA
-
 Homo sapiens
protective protein/cathepsin A
-
 Homo sapiens