Cloned (Comment) | Organism |
---|---|
expressed in T-1 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
R344A | the mutant shows about wild type cathepsin A activity | Homo sapiens |
R344D | inactive mutant, the 54 kDa precursor/zymogen with the R344D substitution is not processed to the 32/20 kDa mature form with CathA activity | Homo sapiens |
R344E | the mutant shows reduced cathepsin A activity compared to the wild type | Homo sapiens |
R344G | the mutant shows reduced cathepsin A activity compared to the wild type | Homo sapiens |
R344I | the mutant shows reduced cathepsin A activity compared to the wild type | Homo sapiens |
R344K | the mutant shows reduced cathepsin A activity compared to the wild type | Homo sapiens |
R344M | the mutant shows reduced cathepsin A activity compared to the wild type | Homo sapiens |
R344N | the mutant shows reduced cathepsin A activity compared to the wild type | Homo sapiens |
R344P | the mutant shows reduced cathepsin A activity compared to the wild type | Homo sapiens |
R344Q | the mutant shows reduced cathepsin A activity compared to the wild type | Homo sapiens |
R344S | the mutant shows about wild type cathepsin A activity | Homo sapiens |
R344V | the mutant shows reduced cathepsin A activity compared to the wild type | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32000 | - |
mature enzyme, SDS-PAGE | Homo sapiens |
54000 | - |
proenzyme, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P10619 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
fibroblast cell line | from a galactosialidosis patient transformed with simian virus-40-adenovirus recombinant | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-L-Phe-L-Leu + H2O | - |
Homo sapiens | benzyloxycarbonyl-L-Phe + L-Leu | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carboxypeptidase Y | - |
Homo sapiens |
CathA | - |
Homo sapiens |
cathepsin A | - |
Homo sapiens |
CPY | - |
Homo sapiens |
EC 3.4.16.1 | formerly | Homo sapiens |
lysosomal protective protein | - |
Homo sapiens |