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Literature summary for 3.4.16.4 extracted from

  • Josephine, H.R.; Charlier, P.; Davies, C.; Nicholas, R.A.; Pratt, R.F.
    Reactivity of penicillin-binding proteins with peptidoglycan-mimetic beta-lactams: whats wrong with these enzymes? (2006), Biochemistry, 45, 15873-15883.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Escherichia coli
-
Streptococcus pneumoniae
-
Actinomadura sp. R39

Inhibitors

Inhibitors Comment Organism Structure
(5R,6R)-6-[[(6S)-6-carboxy-6-(glycylamino)hexanoyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
-
Streptomyces sp. R61
(6R,7R)-3-[(acetyloxy)methyl]-7-[(6S)-6-carboxy-6-(glycylamino)hexanoyl]amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
-
Streptomyces sp. R61
6-beta(alpha-N-acetyl-L-lysyl)-aminopenicillanic acid
-
Streptococcus pneumoniae
6-beta(D-alpha-aminopimelyl)-aminopenicillanic acid
-
Actinomadura sp. R39
6-beta(D-alpha-aminopimelyl)-aminopenicillanic acid
-
Escherichia coli
6-beta(D-alpha-aminosuberyl)-aminopenicillanic acid
-
Actinomadura sp. R39
6-beta(D-alpha-aminosuberyl)-aminopenicillanic acid
-
Escherichia coli
6-beta(N-acetyl-L-alanyl-gamma-D-glutamyl-L-alanyl)-aminopenicillanic acid
-
Escherichia coli
7-beta(alpha-N-acetyl-L-lysyl)-aminocephalosporanic acid
-
Streptococcus pneumoniae
7-beta(D-alpha-aminopimelyl)-aminocephalosporanic acid
-
Actinomadura sp. R39
7-beta(D-alpha-aminopimelyl)-aminocephalosporanic acid
-
Escherichia coli
benzylpenicillin
-
Actinomadura sp. R39
benzylpenicillin
-
Escherichia coli
benzylpenicillin
-
Streptococcus pneumoniae
benzylpenicillin
-
Streptomyces sp. R61
cephalothin
-
Actinomadura sp. R39
cephalothin
-
Escherichia coli
cephalothin
-
Streptococcus pneumoniae
cephalothin
-
Streptomyces sp. R61

Localization

Localization Comment Organism GeneOntology No. Textmining
cell membrane attached to the outer leaflet of the cell membrane Escherichia coli
-
-
cell membrane attached to the outer leaflet of the cell membrane Streptococcus pneumoniae
-
-
cell membrane attached to the outer leaflet of the cell membrane Streptomyces sp. R61
-
-
cell membrane attached to the outer leaflet of the cell membrane Actinomadura sp. R39
-
-

Organism

Organism UniProt Comment Textmining
Actinomadura sp. R39
-
-
-
Escherichia coli
-
-
-
Streptococcus pneumoniae
-
-
-
Streptomyces sp. R61
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli
-
Streptococcus pneumoniae
-
Actinomadura sp. R39

Synonyms

Synonyms Comment Organism
DD-peptidase
-
Escherichia coli
DD-peptidase
-
Streptococcus pneumoniae
DD-peptidase
-
Streptomyces sp. R61
DD-peptidase
-
Actinomadura sp. R39
PBP 2
-
Escherichia coli
PBP 3
-
Streptococcus pneumoniae
PBP 5
-
Escherichia coli
PBP1b
-
Streptococcus pneumoniae
PBP2x
-
Streptococcus pneumoniae
penicillin-binding protein
-
Escherichia coli
penicillin-binding protein
-
Streptococcus pneumoniae
penicillin-binding protein
-
Streptomyces sp. R61
penicillin-binding protein
-
Actinomadura sp. R39

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
Escherichia coli
37
-
-
Streptococcus pneumoniae
37
-
-
Actinomadura sp. R39

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Streptococcus pneumoniae
7.7
-
-
Actinomadura sp. R39
8
-
-
Escherichia coli
8.5
-
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information Ki (5R,6R)-6-[[(6S)-6-carboxy-6-(glycylamino)hexanoyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 15000000 s-1 * M-1 Streptomyces sp. R61
additional information
-
additional information Ki (6R,7R)-3-[(acetyloxy)methyl]-7-[(6S)-6-carboxy-6-(glycylamino)hexanoyl]amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 560000 s-1 * M-1 Streptomyces sp. R61
additional information
-
additional information Ki 6-beta(alpha-N-acetyl-L-lysyl)-aminopenicillanic acid, 12000 s-1 * M-1 Streptococcus pneumoniae
additional information
-
additional information Ki 6-beta(alpha-N-acetyl-L-lysyl)-aminopenicillanic acid, 3900 s-1 * M-1 Streptococcus pneumoniae
additional information
-
additional information Ki 6-beta(alpha-N-acetyl-L-lysyl)-aminopenicillanic acid, 95 s-1 * M-1 Streptococcus pneumoniae
additional information
-
additional information Ki 6-beta(D-alpha-aminopimelyl)-aminopenicillanic acid, 6800000 s-1 * M-1 Actinomadura sp. R39
additional information
-
additional information Ki 6-beta(D-alpha-aminosuberyl)-aminopenicillanic acid, 2850000 s-1 * M-1 Actinomadura sp. R39
additional information
-
additional information Ki 7-beta(alpha-N-acetyl-L-lysyl)-aminocephalosporanic acid, 34 s-1 * M-1 Streptococcus pneumoniae
additional information
-
additional information Ki 7-beta(D-alpha-aminopimelyl)-aminocephalosporanic acid, 11000000 s-1 * M-1 Actinomadura sp. R39
additional information
-
additional information Ki benzylpenicillin, 13000 s-1 * M-1 Streptococcus pneumoniae
additional information
-
additional information Ki benzylpenicillin, 13700 s-1 * M-1 Streptomyces sp. R61
additional information
-
additional information Ki benzylpenicillin, 30000 s-1 * M-1 Streptococcus pneumoniae
additional information
-
additional information Ki benzylpenicillin, 300000 s-1 * M-1 Actinomadura sp. R39
additional information
-
additional information Ki cephalothin, 1400 s-1 * M-1 Streptomyces sp. R61
additional information
-
additional information Ki cephalothin, 65000 s-1 * M-1 Actinomadura sp. R39
additional information
-
additional information Ki cephalothin, 91000 s-1 * M-1 Streptococcus pneumoniae