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Literature summary for 3.4.16.4 extracted from

  • Yocum, R.R.; Waxman, D.J.; Rasmussen, J.R.; Strominger, J.L.
    Mechanism of penicillin action: penicillin and substrate bind covalently to the same active site serine in two bacterial D-alanine carboxypeptidases (1979), Proc. Natl. Acad. Sci. USA, 76, 2730-2734.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.16.4

Inhibitors

Inhibitors Comment Organism Structure
penicillin binds covalently to Ser36, Bacillus subtilis, Bacillus stearothermophilus Bacillus subtilis
penicillin binds covalently to Ser36, Bacillus subtilis, Bacillus stearothermophilus Geobacillus stearothermophilus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Bacillus subtilis 16020
-
membrane
-
 Geobacillus stearothermophilus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine Bacillus subtilis
-
 ?
-
 ?
UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine Geobacillus stearothermophilus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Geobacillus stearothermophilus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine
-
 Bacillus subtilis ?
-
 ?
UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine
-
 Geobacillus stearothermophilus ?
-
 ?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine + H2O
-
 Bacillus subtilis UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanine + D-alanine
-
 ?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine + H2O
-
 Geobacillus stearothermophilus UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanine + D-alanine
-
 ?