Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-benzyloxycarbonyl-prolyl-prolinal | the inhibition of PRCP activity by small molecule protease inhibitors administered peripherally or centrally decreased food intake in both wild-type and obese mice | Mus musculus | |
t-butyl carbamate-prolyl-prolinal | the inhibition of PRCP activity by small molecule protease inhibitors administered peripherally or centrally decreased food intake in both wild-type and obese mice | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
51000 | - |
predicted molecular mass of recombinant PRCP | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-melanocyte-stimulating hormone + H2O | Mus musculus | using recombinant PRCP it is shown that PRCP removes the C-terminal amino acid of alpha-melanocyte-stimulating hormone1-13, producing alpha-melanocyte-stimulating hormone1-12, which is not neuroactive | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
hypothalamus | Prcp is expressed in the hypothalamus in neuronal populations that send efferents to areas where alpha-melanocyte-stimulating hormone1-13 is released from axon terminals | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-melanocyte-stimulating hormone + H2O | using recombinant PRCP it is shown that PRCP removes the C-terminal amino acid of alpha-melanocyte-stimulating hormone1-13, producing alpha-melanocyte-stimulating hormone1-12, which is not neuroactive | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PRCP | - |
Mus musculus |
prolylcarboxypeptidase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.1 | - |
assay at | Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | Prcp-null mice have elevated levels of alpha-melanocyte-stimulating hormone 1-13 in the hypothalamus and aree leaner and shorter than the wild-type controls on a regular chow diet. They are also resistant to high-fat diet-induced obesity | Mus musculus |
physiological function | PRCP is an important component of melanocortin signaling and weight maintenance via control of active alpha-melanocyte-stimulating hormone1-13 levels | Mus musculus |