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Literature summary for 3.4.16.2 extracted from

  • Shariat-Madar, Z.; Mahdi, F.; Schmaier, A.H.
    Recombinant prolylcarboxypeptidase activates plasma prekallikrein (2004), Blood, 103, 4554-4561.
    View publication on PubMed
Search for more literature for 3.4.16.2

Cloned(Commentary)

Cloned (Comment) Organism
cloned in pMT/BIP/V5-HIS-C, transfected into Scheider insect cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
angiotensin II
-
 Homo sapiens
bradykinin
-
 Homo sapiens
diisopropyl fluorophosphonate
-
 Homo sapiens
leupeptin
-
 Homo sapiens
additional information no inhibition by 1 mM EDTA, bradykinin1-5, or angiotensin 1-7 Homo sapiens
phenylmethylsulfonyl fluoride
-
 Homo sapiens
Z-Pro-prolinal
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ optimal activity at 0.01 mM Ca2+ and 1 mM Mg2+ Homo sapiens
Mg2+ optimal activity at 0.01 mM Ca2+ and 1 mM Mg2+ Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is a plasma prekallikrein activator ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is a plasma prekallikrein activator Homo sapiens ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1
-
-
 Homo sapiens