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Literature summary for 3.4.15.4 extracted from

  • Soler, D.F.; Harris, R.B.
    Atrial dipeptidyl carboxyhydrolase is a zinc-metallo proteinase which possesses tripeptidyl carboxyhydrolase activity (1989), Peptides, 10, 63-68.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Benzoyl-Asn-Ser-Phe-Arg-Tyr-NH2 competitive inhibitor of 2-aminobenzoyl-Gly-Ala-Phe(4-nitro)-Arg hydrolysis and benzoyl-Asn-Ser-Phe-Arg-Tyr hydrolysis Bos taurus
EDTA activity is restored by addition of Co2+, Zn2+ and Mn2+, but not by Cu2+, Mg2+, Ca2+ or Cd2+ Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
2-Aminobenzoyl-Gly-Thr-(4-nitro)Phe-Arg [mercaptopropionyl105,(D)Ala107]-atriopeptin III-NH2 Bos taurus
0.27
-
Atriopeptin I
-
Bos taurus
0.124
-
Atriopeptin I
-
Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc metallopeptidase Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
atrium
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information generally restricted to the release of dipeptides. In contrast to peptidyl-dipeptidase A (EC 3.4.15.1) it shows no action on angiotensin I. Conversely, peptidyl-dipeptidase A is unable to release Phe-Arg from the C-terminus of atriopeptin II Bos taurus ?
-
?
additional information not: benzoyl-Asn-Ser-Phe-Arg-Tyr-NH2 Bos taurus ?
-
?
Atriopeptin II peptide Ser103-Arg125 + H2O
-
Bos taurus Atriopeptin I peptide Ser103-Ser123 + Phe-Arg
-
?
Atriopeptin III peptide Ser103-Tyr126 + H2O
-
Bos taurus Atriopeptin I + Phe-Arg-Tyr
-
?
[Mercaptopropionyl105,(D)Ala107]-atriopeptinIII-NH2 peptide + H2O enzyme acts exclusively as tripeptidyl carboxyhydrolase Bos taurus Analog(1-18) + Phe-Arg-Tyr-NH2
-
?
Benzoyl-Asn-Ser-Phe-Arg-Tyr + H2O
-
Bos taurus Benzoyl-Asn-Ser-Phe + Arg-Tyr successive dipeptidyl cleavage after longer incubation yielding benzoyl-Asn + Ser-Phe ?
2-aminobenzoyl-Gly-Ala-(4-nitro)Phe-Arg + H2O
-
Bos taurus 2-aminobenzoyl-Gly-Ala + 4-nitro-L-phenylalanyl-L-arginine
-
?
2-aminobenzoyl-Gly-Thr-(4-nitro)Phe-Arg + H2O
-
Bos taurus 2-aminobenzoyl-Gly-Thr + 4-nitro-L-phenylalanyl-L-arginine
-
?