Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Benzoyl-Asn-Ser-Phe-Arg-Tyr-NH2 | competitive inhibitor of 2-aminobenzoyl-Gly-Ala-Phe(4-nitro)-Arg hydrolysis and benzoyl-Asn-Ser-Phe-Arg-Tyr hydrolysis | Bos taurus | |
EDTA | activity is restored by addition of Co2+, Zn2+ and Mn2+, but not by Cu2+, Mg2+, Ca2+ or Cd2+ | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
2-Aminobenzoyl-Gly-Thr-(4-nitro)Phe-Arg | [mercaptopropionyl105,(D)Ala107]-atriopeptin III-NH2 | Bos taurus | |
0.124 | - |
Atriopeptin I | - |
Bos taurus | |
0.27 | - |
Atriopeptin I | - |
Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zinc | metallopeptidase | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
atrium | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-aminobenzoyl-Gly-Ala-(4-nitro)Phe-Arg + H2O | - |
Bos taurus | 2-aminobenzoyl-Gly-Ala + 4-nitro-L-phenylalanyl-L-arginine | - |
? | |
2-aminobenzoyl-Gly-Thr-(4-nitro)Phe-Arg + H2O | - |
Bos taurus | 2-aminobenzoyl-Gly-Thr + 4-nitro-L-phenylalanyl-L-arginine | - |
? | |
Atriopeptin II peptide Ser103-Arg125 + H2O | - |
Bos taurus | Atriopeptin I peptide Ser103-Ser123 + Phe-Arg | - |
? | |
Atriopeptin III peptide Ser103-Tyr126 + H2O | - |
Bos taurus | Atriopeptin I + Phe-Arg-Tyr | - |
? | |
Benzoyl-Asn-Ser-Phe-Arg-Tyr + H2O | - |
Bos taurus | Benzoyl-Asn-Ser-Phe + Arg-Tyr | successive dipeptidyl cleavage after longer incubation yielding benzoyl-Asn + Ser-Phe | ? | |
additional information | generally restricted to the release of dipeptides. In contrast to peptidyl-dipeptidase A (EC 3.4.15.1) it shows no action on angiotensin I. Conversely, peptidyl-dipeptidase A is unable to release Phe-Arg from the C-terminus of atriopeptin II | Bos taurus | ? | - |
? | |
additional information | not: benzoyl-Asn-Ser-Phe-Arg-Tyr-NH2 | Bos taurus | ? | - |
? | |
[Mercaptopropionyl105,(D)Ala107]-atriopeptinIII-NH2 peptide + H2O | enzyme acts exclusively as tripeptidyl carboxyhydrolase | Bos taurus | Analog(1-18) + Phe-Arg-Tyr-NH2 | - |
? |