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Literature summary for 3.4.15.4 extracted from

  • Soler, D.F.; Harris, R.B.
    Continuous fluorogenic substrates for atrial dipeptidyl carboxyhydrolase. Importance of Ser in the P1 position (1988), Int. J. Pept. Protein Res., 32, 35-40.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
2-Aminobenzoyl-Gly-Thr-(4-nitro)Phe-Arg
-
Bos taurus
0.09
-
2-Aminobenzoyl-Gly-Asp-(4-nitro)Phe-Arg
-
Bos taurus
0.12
-
benzoyl-Gly-Ser-Phe-Arg
-
Bos taurus
0.14
-
2-Aminobenzoyl-Gly-Ser-(4-nitro)Phe-Arg
-
Bos taurus
0.102
-
2-Aminobenzoyl-Gly-Ala-(4-nitro)Phe-Arg
-
Bos taurus
0.213
-
2-Aminobenzoyl-Gly-Asp-(4-nitro)Phe-Arg
-
Bos taurus
0.129
-
2-Aminobenzoyl-Gly-Lys-(4-nitro)Phe-Arg
-
Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
atrium
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-aminobenzoyl-Gly-Ser-(4-nitro)Phe-Arg + H2O
-
Bos taurus 2-aminobenzoyl-Gly-Ser + 4-nitro-L-phenylalanyl-L-arginine
-
?
2-aminobenzoyl-Gly-Ala-(4-nitro)Phe-Arg + H2O
-
Bos taurus 2-aminobenzoyl-Gly-Ala + 4-nitro-L-phenylalanyl-L-arginine
-
?
2-aminobenzoyl-Gly-Lys-(4-nitro)Phe-Arg + H2O
-
Bos taurus 2-aminobenzoyl-Gly-Lys + 4-nitro-L-phenylalanyl-L-arginine
-
?
2-aminobenzoyl-Gly-Asn-(4-nitro)Phe-Arg + H2O
-
Bos taurus 2-aminobenzoyl-Gly-Asn + 4-nitro-L-phenylalanyl-L-arginine
-
?
2-aminobenzoyl-Gly-Thr-(4-nitro)Phe-Arg + H2O
-
Bos taurus 2-aminobenzoyl-Gly-Thr + 4-nitro-L-phenylalanyl-L-arginine
-
?
2-aminobenzoyl-Gly-Asp-(4-nitro)Phe-Arg + H2O
-
Bos taurus 2-aminobenzoyl-Gly-Asp + 4-nitro-L-phenylalanyl-L-arginine
-
?
Benzoyl-Gly-Phe-Ser-Arg + H2O
-
Bos taurus ?
-
?
benzoyl-Gly-Ser-Phe-Arg + H2O
-
Bos taurus benzoyl-Gly-Ser + Phe-Arg
-
?

pH Range

pH Minimum pH Maximum Comment Organism
6.5 9 6.5: about 65% of activity maximum, 9: about 60% of activity maximum Bos taurus