Inhibitors | Comment | Organism | Structure |
---|---|---|---|
captopril | - |
Rattus norvegicus | |
EDTA | - |
Rattus norvegicus | |
S-acetylcaptopril | - |
Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
165000 | - |
x * 165000, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O | Rattus norvegicus | i.e. substance P, lung and brain ACE cleave substance P via two pathways. In one pathway ACE first releases Gly-Leu-Met-NH2 and then dipeptides sequentially from the carboxyl terminus. The other first produces Leu-Met-NH2 and then releases dipeptides to leave substance P(1-5) | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | corpus striatum | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O | i.e. substance P | Rattus norvegicus | Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly + Leu-Met-NH2 | - |
? | |
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O | lung and brain ACE cleave substance P via two pathways. In one pathway ACE first releases Gly-Leu-Met-NH2 and then dipeptides sequentially from the carboxyl terminus. The other first produces Leu-Met-NH2 and then releases dipeptides to leave substance P(1-5) | Rattus norvegicus | Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly + Leu-Met-NH2 | - |
? | |
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O | i.e. substance P, lung and brain ACE cleave substance P via two pathways. In one pathway ACE first releases Gly-Leu-Met-NH2 and then dipeptides sequentially from the carboxyl terminus. The other first produces Leu-Met-NH2 and then releases dipeptides to leave substance P(1-5) | Rattus norvegicus | ? | - |
? | |
hippuryl-His-Leu + H2O | - |
Rattus norvegicus | hippuric acid + His-Leu | - |
? | |
His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 + H2O | i.e. substance K, degraded by striatal but not by lung enzyme | Rattus norvegicus | His-Lys-Thr-Asp-Ser-Phe-Val-Gly + Leu-Met-NH2 | - |
? | |
Luteinizing hormone-releasing hormone + H2O | degraded by striatal and by lung enzyme | Rattus norvegicus | ? | - |
? | |
N-(1-(S)-carboxy-3-phenylpropyl)-L-Ala-L-Pro + H2O | i.e. MK-422 | Rattus norvegicus | ? | - |
? | |
N-(1-(S)-carboxy-3-phenylpropyl)-L-Lys-L-Pro + H2O | i.e. MK-522 | Rattus norvegicus | ? | - |
? | |
physalaemin + H2O | degraded by striatal and by lung enzyme | Rattus norvegicus | pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly + Leu-Met-NH2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 165000, SDS-PAGE | Rattus norvegicus |