Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Cl- | - |
Homo sapiens | |
Cl- | required for hydrolysis of angiotensin I, not required for hydrolysis of bradykinin | Mammalia |
Cloned (Comment) | Organism |
---|---|
somatic enzyme form | Mus musculus |
somatic enzyme form | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
9-[1-carboxy-3-(4-hydroxyphenyl)propylamino]octahydro-10-oxo-6H-pyridazo[1,2-a][1,2]diazepine-1-carboxylic acid | - |
Mammalia | |
captopril | i.e. D-(3-mercapto-2-methylpropanoyl)-L-Pro | Homo sapiens | |
captopril | i.e. D-(3-mercapto-2-methylpropanoyl)-L-Pro | Mammalia | |
captopril | - |
Rattus norvegicus | |
enaprilat | - |
Homo sapiens | |
enaprilat | i.e. N-[(S)-1-carboxy-3-phenylpropyl]-Ala-Pro | Mammalia | |
enaprilat | - |
Rattus norvegicus | |
lisinopril | - |
Homo sapiens | |
lisinopril | i.e. N-[(S)-1-carboxy-3-phenylpropyl]-L-Lys-L-Pro | Mammalia |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Mammalia | |
additional information | - |
additional information | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | anchored to plasma membrane, the bulk of its mass exposed at the extracellular surface of the cell | Mammalia | 16020 | - |
membrane | inserted in plasma membrane via the carboxyl terminus | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zinc | - |
Homo sapiens | |
Zinc | required | Mammalia |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
90000 | 110000 | germinal cells, germinal cells also contain an enzyme form of MW 150000-180000 Da, gel filtration | Mammalia |
150000 | 180000 | somatic enzyme form in endothelial, epithelial, neuronal, and germinal cells, in germinal cells a second enzyme form of 90000-110000 Da exists, gel filtration | Mammalia |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | - |
? | - |
? | |
additional information | Rattus norvegicus | - |
? | - |
? | |
additional information | Mammalia | the enzyme enhances presentation of certain endogenously synthesized peptides to major histocompatibility complex class-I-restricted cytotoxic T-lymphocytes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mammalia | - |
two ACE forms: a somatic form of MW 150000-180000 Da and a smaller isoform of MW 90009-110000 Da in germinal cells | - |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
side-chain modification | glycoprotein | Mammalia |
side-chain modification | glycoprotein | Homo sapiens |
side-chain modification | glycoprotein | Rattus norvegicus |
side-chain modification | somatic enzyme form contains 17 potential glycosylation sites but no Ser/Thr-rich region indicative of O-glycosylation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelium | - |
Homo sapiens | - |
endothelium | vascular | Mammalia | - |
epithelium | brush border of absorptive epithelia on the small intestine and the renal convoluted tubule | Mammalia | - |
germ | - |
Mammalia | - |
kidney | - |
Mus musculus | - |
kidney | - |
Homo sapiens | - |
kidney | - |
Rattus norvegicus | - |
lung | - |
Homo sapiens | - |
lung | - |
Rattus norvegicus | - |
macrophage | - |
Mammalia | - |
monocyte | - |
Mammalia | - |
neuron | - |
Mammalia | - |
T-lymphocyte | - |
Mammalia | - |
testis | - |
Mammalia | - |
testis | - |
Homo sapiens | - |
testis | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | - |
Mammalia | angiotensin II + His-Leu | - |
? | |
angiotensin I + H2O | - |
Mus musculus | angiotensin II + His-Leu | - |
? | |
angiotensin I + H2O | - |
Homo sapiens | angiotensin II + His-Leu | - |
? | |
beta-neoendorphin + H2O | - |
Mammalia | ? | - |
? | |
bradykinin + H2O | - |
Mammalia | Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe | - |
? | |
bradykinin + H2O | - |
Homo sapiens | Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe | - |
? | |
bradykinin + H2O | - |
Rattus norvegicus | Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe | - |
? | |
cholecystokinin-8 + H2O | - |
Mammalia | ? | - |
? | |
dynorphin + H2O | - |
Mammalia | ? | - |
? | |
hippuryl-Gly-Gly + H2O | - |
Mammalia | hippuric acid + Gly-Gly | - |
? | |
hippuryl-Gly-Gly + H2O | - |
Homo sapiens | hippuric acid + Gly-Gly | - |
? | |
hippuryl-His-Leu + H2O | - |
Homo sapiens | hippuric acid + His-Leu | - |
? | |
hippuryl-His-Leu + H2O | - |
Rattus norvegicus | hippuric acid + His-Leu | - |
? | |
Met5-enkephalin + H2O | - |
Mammalia | Tyr-Gly-Gly + Phe-Met | - |
? | |
Met5-enkephalin + H2O | - |
Homo sapiens | Tyr-Gly-Gly + Phe-Met | - |
? | |
Met5-enkephalin-Arg6-Gly7-Leu8 + H2O | - |
Mammalia | Tyr-Gly-Gly-Phe-met-Arg + Gly-Leu | - |
? | |
additional information | - |
Homo sapiens | ? | - |
? | |
additional information | - |
Rattus norvegicus | ? | - |
? | |
additional information | the enzyme enhances presentation of certain endogenously synthesized peptides to major histocompatibility complex class-I-restricted cytotoxic T-lymphocytes | Mammalia | ? | - |
? | |
neurotensin + H2O | - |
Mammalia | pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr + Ile-Leu | - |
? | |
neurotensin + H2O | - |
Homo sapiens | pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr + Ile-Leu | - |
? |